NFIC overexpression reversed the inhibitory effect of miR‐143‐3p on the odontogenic differentiation of hSCAPs. Conclusions miR‐143‐3p maintained the stemness of hSCAPs and modulated their differentiation negatively by directly targeting NFIC . Thus, inhibition of this miRNA represents a potential ...
miRNA‐124‐3p/neuropilin‐1(NRP‐1) axis plays an important role in mediating glioblastoma growth and angiogenesis 喜欢 0 阅读量: 45 作者:Zhang,Guilong,Chen,Lukui,Khan,Ahsan,Ali,Li,Bingqian,Gu 摘要: Glioblastoma multiforme (GBM) is the most lethal b ...
[目的]探究miRNA-143-3P在从江香猪与杂交猪之间是否存在表达水平的差异性,预测分析该miRNA的靶基因及其功能,分析miR-143-3P在这两个猪种中的功能.[方法]通过RT-qPCR检测从江香猪与杂交猪中不同组织的miRNA-143-3P,利用线软件预测miRNA-143-3P的靶基因,对筛选的靶基因作生物信息学分析,了解miRNA-143靶基因... ...
结果正常脑组织中miRNA-143-3p与Ki-67均为阴性表达.高级别胶质瘤中miRNA-143-3p与Ki-67的阳性率均明显高于低级别胶质瘤,差异均有统计学意义(P<0.05).miRNA-143-3p与Ki-67蛋白在胶质瘤组织中呈正相关(r=0.964,P<0.05).结论 miRNA-143-3p可有效反映胶质瘤的病变程度,并且miRNA-143-3p与Ki-67联合检测可...