证实了miRNA-124-3p的上调明显抑制hipk3-WT荧光素酶的活性,miRNA-124-3p与Hipk3之间存在结合位点.4,AngⅡ诱导的心肌肥大中,Hipk3表达量显著上升,且在H9C2细胞中过表达Hipk3可以导致心肌细胞表面积的增大和心肌肥厚因子水平的上升.5,过表达Hipk3可以部分逆转miRNA-124-3p的抗心肌肥厚作用.结论:miRNA-124-3p...
Firstly, we identified that hsa-miR-124-3p was miRNA differentially expressed in GBM and in normal brain tissues by high-throughput sequencing. Then, by dual luciferase reporter gene, we found miR-124-3p can specially bind to the 3'UTR region of the NRP-1 thus suppresses its expression. ...
The relative expressions of miR-124-3p, miR-132-3p, miR-214-5p, and LPIN1 were calculated via the 2−ΔΔCt method, GAPDH, and U6 were served as the internal control. Table 4. Primary sequences. Gene/miRNAPrimary miR-124-3p Forward: 5′-TGCGGTAAGGCACGCGGTGAATGCC-3′ Reverse: 5...
miRNA-124-3p.1 Inhibits the Osteogenic and Odontogenic Differentiation of SCAPs via MACF1/smad7 Axis 来自 Semantic Scholar 喜欢 0 阅读量: 78 作者:N Li,Z Li,M Yan,J Yu 摘要: Background: Previous research has indicated that altered expression of micro-RNAs (miRNAs) is in connection with ...
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA‐124‐3p/STAT3/RelA signalling pathway in ulcerative colitisdoi:10.1111/jcmm.15726Luo, YangYu, Min‐HaoYan, Ya‐RuZhou, YongQin, Shao‐LanHuang, Yi‐ZhouQin, Jun...
分别检测两组miRNA-124-3p,miRNA-148b-3p,血肌酐(Scr),C-反应蛋白(CRP),降钙素原(PCT),肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6)和白细胞介素-10(IL-10)指标的水平,采用独立样本t检验方法检验两组上述指标是否具有统计学意义.采用Pearson相关分析miRNA-124-3p,miRNA-148b-3p水平与Scr,CRP,PCT,...
miRNA‐124‐3p/neuropilin‐1(NRP‐1) axis plays an important role in mediating glioblastoma growth and angiogenesis 喜欢 0 阅读量: 45 作者:Zhang,Guilong,Chen,Lukui,Khan,Ahsan,Ali,Li,Bingqian,Gu 摘要: Glioblastoma multiforme (GBM) is the most lethal b ...
MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1TRANSCRIPTION FACTORSCANCER-CELLSRESISTANCEAPOPTOSISPROLIFERATIONPROGRESSIONMETASTASISSURVIVALAs a multikinase inhibitor, sorafenib is commonly used to treat patients with advanced hepatocellular ...
miRNA-124-3pMalignant glioma is the most common primary malignancy in the brain. It is aggressive, highly invasive, and destructive. Studies have shown that sevoflurane can affect the invasion and migration of a variety of malignant tumors. However, its effects on human glioma cells and related ...
The target miR mimic was introduced into them, and the changes in migration ability were evaluated.Results: miR-124-3p.2 was extracted as a candidate from miRNA PCR Plate Array and Target Scan. miR-124-3p.2 expression was upregulated in both LNCaP and C4-2B when DHT was added and ...