证实了miRNA-124-3p的上调明显抑制hipk3-WT荧光素酶的活性,miRNA-124-3p与Hipk3之间存在结合位点.4,AngⅡ诱导的心肌肥大中,Hipk3表达量显著上升,且在H9C2细胞中过表达Hipk3可以导致心肌细胞表面积的增大和心肌肥厚因子水平的上升.5,过表达Hipk3可以部分逆转miRNA-124-3p的抗心肌肥厚作用.结论:miRNA-124-3p...
miRNA-124-3p通过靶向STAT3抑制鼻咽癌细胞生长和转移 作者:许珊; 李巍; 赵宁; 苗滋伟; 宋敏; 姜学钧鼻咽癌增殖凋亡迁移侵袭 摘要:目的:探讨miR-124-3p在鼻咽癌中的表达及其对鼻咽癌细胞的影响及其机制。方法:收集鼻咽癌组织标本90例和慢性鼻咽炎症组织标本85例,运用qRT-PCR方法检测组织标本和CNE1、CNE2、SUNE1、...
Firstly, we identified that hsa-miR-124-3p was miRNA differentially expressed in GBM and in normal brain tissues by high-throughput sequencing. Then, by dual luciferase reporter gene, we found miR-124-3p can specially bind to the 3'UTR region of the NRP-1 thus suppresses its expression. ...
We found that SF inhibits total STAT3 expression level and STAT3 phosphorylation (troy 704 and troy 705) by upregulation of miRNA-124-3p. Our results provide the evidence for discovering the novel drugs against nasopharyngeal carcinoma, and potential drugs targeting STAT3 signaling pathway....
Rab27A promotes cellular apoptosis and ROS production by regulating the miRNA‐124‐3p/STAT3/RelA signalling pathway in ulcerative colitisdoi:10.1111/jcmm.15726Luo, YangYu, Min‐HaoYan, Ya‐RuZhou, YongQin, Shao‐LanHuang, Yi‐ZhouQin, Jun...
miRNA-1 24-3 p/neuropilin- 1(NRP-1 ) axis plays an important role in mediating glioblastoma growth and angiogenesis. Int J Cancer. 2018;143(3):635‐644.Zhang, G.; Chen, L.; Khan, A.A.; Li, B.; Gu, B.; Lin, F.; Su, X.; Yan, J. miRNA-1...
MiRNA-124-3p.1 sensitizes hepatocellular carcinoma cells to sorafenib by regulating FOXO3a by targeting AKT2 and SIRT1TRANSCRIPTION FACTORSCANCER-CELLSRESISTANCEAPOPTOSISPROLIFERATIONPROGRESSIONMETASTASISSURVIVALAs a multikinase inhibitor, sorafenib is commonly used to treat patients with advanced hepatocellular ...
Differentially expressed miRNAs were identified, revealing the effect of miR-124-3p on adipogenic differentiation by targeting C/EBPα . Our results provide both a comprehensive understanding of miRNA expression patterns in sheep subcutaneous fat, and an insight into the specific roles of miRNAs in ...
分别检测两组miRNA-124-3p,miRNA-148b-3p,血肌酐(Scr),C-反应蛋白(CRP),降钙素原(PCT),肿瘤坏死因子-α(TNF-α),白细胞介素-6(IL-6)和白细胞介素-10(IL-10)指标的水平,采用独立样本t检验方法检验两组上述指标是否具有统计学意义.采用Pearson相关分析miRNA-124-3p,miRNA-148b-3p水平与Scr,CRP,PCT,...
结果 miRNA-124-3p抑制剂组和Wnt1 siRNA组心肌细胞Wnt1及β-catenin表达水平降低.CCK-8检测结果显示,与OGD组比较,miRNA-124-3p抑制剂组和Wnt1 siRNA组心肌细胞活性增高,而二者比较,差异无统计学意义(P>0.05).Western blot结果显示,与OGD组比较,miRNA-124-3p抑制剂组和Wnt1 siRNA组p53,Bcl-2表达水平升高,Bax...