［摘要］ 背景与目的：MicroRNA(miRNA,miR)是一类可负性调控基因表达的非编码小RNA，能通过与mRNA 分子相互作用阻遏蛋白质翻译或导致RNA降解；且在肿瘤的发生、发展中扮演着重要的角色。本研究旨在探讨microRNA-338-3p(miR-338-3p)在结直肠癌与癌旁组织中差异表达状况及其与临床病理特征和预后之间的关系。方法：选...
microRNA-338-3poxidized low-density lipoprotein (ox-LDL)TGF-β/Smad pathwaymicroRNAs (miRNAs) have been revealed to participate in the pathological process of atherosclerosis (AS). However, the exact role of miR-338-3p, a target miRNA of BMP and activin membrane-bound inhibitor (BAMBI), and...
第一部分结直肠癌与毗邻癌旁组织中microRNA-338-3p与Smoothened的差异表达目的:目前研究发现miRNA能调节肿瘤细胞的增殖分化及侵袭转移,MiR.338.3p是新发现的一种rniRNA并参与了部分肿瘤的发生发展,但miRNA.338.3p调控哪些信号通路及其在结直肠癌中的作用机制目前尚不清楚,故本研究旨在观察结直肠癌与毗邻癌旁组织中...
Fig 2C from "MicroRNA-379 suppresses cell proliferation, migration and invasion in nasopharyngeal carcinoma by targeting tumor protein D52" (Zhao & Chu 2018). Fig 2C from "MicroRNA‑365b‑3p represses the proliferation and promotes the apoptosis of non‑small cell lung cancer cells by ta...
There are comments on PubPeer for publication: MicroRNA-338-3p functions as tumor suppressor in breast cancer by targeting SOX4 (2015)
Osteosarcoma (OS) is a rare, malignant bone tumor that primarily affects adolescents and has a high degree of malignancy and high incidence of recurrence and metastasis. Our study aimed to explore the role of miR-338-3p in OS cells. qRT-qPCR was performe
MicroRNA-338-3p has been reported to be a tumor suppressor in multiple cancer types. However, the biological role of miR-338-3p and underlying mechanism in multiple myeloma (MM) remains unclear. In the present study, we investigate the biological role and potential of miR-338-3p in MM. We...
外泌体修饰微小RNAs的制备: 外泌体是一类介导体内生物信息分子传递的纳米级小囊泡",外泌体能在体内运载和传递生物信息分子,在免疫调节、心血管疾病和肿瘤等生理病理过程中发挥着重要的功能。外泌体可由体内各种活细胞分泌,体液中含量很高,每微升血清中外泌体数量可达3× 106其携带的RNA、蛋白质和脂类等生物信息分...
MicroRNA-338-3p suppresses cell proliferation and induces apoptosis of non-small-cell lung cancer by targeting sphingosine kinase 2. Cancer Cell Int. 2017;17:46.Wang Z, Ma B, Ji X, Deng Y, Zhang T, Zhang X, Gao H, Sun H, Wu H, Chen X, Zhao R. MicroR- NA-378-5p suppresses ...
miRNA-338-3p mimic降低了Smad3的3'UTR野生型的荧光素酶活性,而突变型并没有明显差异;通过促进miRNA-338-3p的过表达,q PCR和WB结果表明,Smad2和Smad3的m RNA及蛋白表达均出现降低;ELISA实验结果显示,过表达miRNA-338-3p后Col1和Col3的表达下调.结论:Micro RNA-338-3p可抑制缺氧诱导的BMSCs细胞外基质的表达....