在本研究中,研究者首次报道了富含microRNA-124-3p 的SEV对帕金森病的治疗潜力。SEV携带miR-124-3p在体外生理条件下诱导SVZ神经干细胞向神经元分化。在体内,研究者发现侧脑室注射miR-124-3p SEV可以保护黑质纹状体通路免受6-OHDA诱导的神经变性的影响,并显著改善受损小鼠的运动能力。研究者的发现支持使用miR-124-3p...
在本研究中,研究者首次报道了富含microRNA-124-3p 的SEV对帕金森病的治疗潜力。SEV携带miR-124-3p在体外生理条件下诱导SVZ神经干细胞向神经元分化。在体内,研究者发现侧脑室注射miR-124-3p SEV可以保护黑质纹状体通路免受6-OHDA诱导的神经变性的...
在本研究中,研究者首次报道了富含microRNA-124-3p 的SEV对帕金森病的治疗潜力。SEV携带miR-124-3p在体外生理条件下诱导SVZ神经干细胞向神经元分化。在体内,研究者发现侧脑室注射miR-124-3p SEV可以保护黑质纹状体通路免受6-OHDA诱导的神经变性的影响,并显著改善受损小鼠的运动能力。研究者的发现支持使用miR-124-3p...
microRNA-124-3pTh17细胞白细胞介素-17A为探讨microRNA-124-3p(miR-124-3P)对Th17细胞体外分化的影响,本研究通过密度梯度离心获取小鼠脾脏单淋巴细胞悬液,运用免疫磁珠法分选幼稚T细胞,然后用腺病毒表达载体转染幼稚T细胞,介导miR-124-3P过表达和抑制表达,并设空白对照组,加入Th17细胞分化相关细胞因子,诱导幼稚T细胞向...
MicroRNA1323p regulates cell proliferation, apoptosis, migration and invasion of liver cancer by targeting Sox4 Li, L. Xue, N. Shao, Q. Wang, X. Xia, Y. Yang, F. Zhi, MicroRNA-124-3p regulates cell proliferation, invasion, apoptosis, and bioenergetics by targeting PIM1 in astrocytoma, ...
Initially, hepatic I/R animal models and I/R hepatocyte models were established in C57BL/6 mice and normal mouse hepatocytes (BNL CL.2) after SEV preconditioning, respectively, followed by detection of microRNA-124-3p (miR-124-3p), TRAF3, and CREB expression by RT-qPCR and Western blot ...
MicroRNA-124-3p inhibits cell migration and invasion in bladder cancer cells by targeting ROCK1. Xu X,Li S,Lin Y, et al. Journal of Translational Medicine . 2013Xu X, Li S, Lin Y, Chen H, Hu Z, Mao Y, Xu X, Wu J, Zhu Y, Zheng X, Luo J, Xie L (2013) MicroRNA-124-3p...
MicroRNA-124 has been regarded as a promising therapeutic entity for Parkinson's disease due to its pro-neurogenic and neuroprotective roles. However, its efficient delivery to the brain remains challenging. Here, we used umbilical cord blood mononuclear cell-derived extracellular vesicles as a ...
MicroRNA‐124‐3p suppresses PD‐L1 expression and inhibits tumorigenesis of colorectal cancer cells via modulating STAT3 signalingColorectal cancermiRNA‐124PD‐L1STAT3Programmed death ligand 1 (PD㎜1) plays a significant role in colorectal tumorigenesis through induction of regulatory T cells (Tregs) ...
In this case, we targeted to explore in detail the relative mechanism of microRNA (miR)-124-3p in sepsis-induced myocardial injury via the specific protein 1/histone deacetylase 4/hypoxia-inducing factor 1α (SP1/HDAC4/HIF-1α) axis. Septic rats were modeled by cec...