敲除miR-449a-5p后,i-EVs的免疫抑制功能显著下降,这提示miR-449a-5p在iTreg-EVs抑制免疫过程中发挥了关键作用。 图2 miR-449a-5p对于iTreg-EVs的免疫抑制功能至关重要 接下来作者测试了EVs在体内治疗自身免疫性关节炎的效果。实验结...
Together, these data indicated that the miR449a/SIRT1/deacetylated PGC-1α axis plays an essential role in the ability of moderate concentrations of T-2 toxin to stimulate mitochondrial biogenesis and ROS production. 展开 关键词: T-2 toxin mitochondrial biogenesis miR-449a SIRT1 PGC-1α ...
Bioinformatics, co-expression analysis, and a luciferase assay indicated that circPTGR1 competed with MET to target miR449a. Interpretation Higher metastatic HCC cells can confer this potential on those with lower or no metastatic potential via exosomes with circPTGR1, resulting in increased ...