Overall, present study also provides indications that that more intensive gene therapies and fibrosis level evaluations are needed for the management of chronic fibrosis patients. Experimental section Diabetic animal models Briefly, intraperitoneally administered the 50 mg/kg of streptozotocin (STZ) to the...
related gene Western blot analysis showed that,the expression of CyclinE,CDK2, PCNA,UBC9 and K5 gradually increased after balloon injury which consisted with the neointimal hyperplasia. 3The expression of miR.29a increases in the intimal hyperplasia Real.time PCR results showed that the expression ...
Functional miR29a gene polymorphism enhanced the risk of chronic kidney disease in an Iranian population: A preliminary case-control study and bioinformatics analysesdoi:10.1016/j.mgene.2020.100755Fariba Mirani SargaziA. AlidadiH. TaheriMilad Heidari Nia...
Gene polymorphismMicroRNAs, miR29aRecurrent spontaneous abortion (RSA) is a multifactorial disorder, and multiple genetic and environmental factors affect its pathogenesis. Recently, microRNA polymorphisms have been significantly associated with RSA incidence. This study aimed to evaluate the impact of miR2...
MiRNAs are a class of small, non-coding, single-stranded RNAs that regulate gene expression primarily through transcriptional repression of mRNA. We showed miR29a modulates ADAM12 expression in the setting of type 1 DM and ischemia. However, how miR29a modulates ADAM12 was not known. Moreover,...
Our result reveals for the first time that inhibiting elevated microRNAs may be a more effective therapeutic approach than gene transfer to improve blood flow and muscle function in type 2 DM and PAD.doi:10.1210/jendso/bvaa046.2211Victor Lamin...
Furthermore, we identified that Fstl1 was a target gene of miR29a. And TGF-β1 induction of Fstl1 expression was partially through down regulation of miR29a in HSCs.Our data suggests TGF-β1-miR29a-Fstl1 regulatory circuit plays a key role in regulation the HSC activation and ECM ...
hsa-miR-29a-3p has been identified as a potential regulator of the Negative Regulatory Factor (Nef) gene from the HIV-1 viral genome. In this study, we aimed to compare the serum levels of hsa-miR-29a-3p with HIV-1 viral load in a substantial number of infected individuals. We ...
The Gene Expression Omnibus (GEO) dataset was used to corroborate the differential expression and diagnostic value of MIR29A . The bioinformatic identification were conducted to examine the interaction of MIR29A with LOX , LOXL2 , and VEGFA . The suppressive activity of MIR29A on LOX , LOXL2 ...
Overexpression ofMIR29A-3p mimic in HepG2 cells led to downregulated gene and protein expression levels ofLOX,LOXL2, andVEGFA, wherein luciferase reporter assay confirmed thatMIR29A-3p exerts the inhibitory activity via directly binding to the 3'UTR ofLOXandVEGFA. Furthermore, overexpression of...