miR-199a-1myotubularin 1 (Mtm1)X-linked centronuclear myopathy (XLCNM)Mutations in the myotubularin 1 ( MTM1 ) gene can cause the fatal disease X-linked centronuclear myopathy (XLCNM), but the underlying mechanism is incompletely understood. In this report, using an Mtm1 /y disease model...
miR-199a-5p脂质累积ABCA1目的:丙戊酸(Valproic acid,VPA)是一种广谱抗癫痫药物,用于癫痫发作的单药治疗和辅助治疗.VPA在监测其血药浓度水平时,毒性作用不常见,但高于治疗水平时可引起毒性作用,其中肝毒性为严重的不良反应之一,与肝脏内脂质的蓄积相关.长期使用VPA会导致甘油三酯(triglyceride,TG)在肝脏的积聚,最终...
In this report, using an Mtm1−/y disease model, we found that expression of the intragenic microRNA miR-199a-1 is up-regulated along with that of its host gene, dynamin 2 (Dnm2), in XLCNM skeletal muscle. To assess the role of miR-199a-1 in XLCNM, we crossed miR-199a-1...
The present invention relates to the use of the miRNA expression profile, particularly of miR-199a-5p, and the target genes regulated thereby for the diagnosis, prognosis and use of miR-199a-5p inhibitors for treating fibroproliferative disorders.ポッティエ,ニコラス...