miR-196a2单核苷酸多态性TRP-1氧化应激白癜风是皮肤科常见的获得性色素脱失性疾病,以皮损部位黑素细胞明显减少或消失为特征.黑素细胞破坏或凋亡的机理迄今尚未完全阐明,白癜风的发病机制的研究多集中在自身免疫,神经因子,氧化应激,代谢毒素,遗传等学说.越来越多的学者认为,白癜风的发生和进展是多因素多基因共同作用的,...
miR.423在乳腺癌中的功能,本研究首先检测了miR.196a2SNP位点rsll614913 及miR.423SNP位点rs6505162在5对细胞系及114对组织中的突变情况。结果 显示:14%的组织中miR.196a2SNP位点rsll614913发生了体细胞突变,并且 成熟miR.196a2的表达与体细胞突变及临床病理指标组织学分级显著相关。 miR.423SNP位点rs6505162在...
A functional polymorphism in MIR196A2 is associated with risk and prognosis of gastric cancer. Molecular Carcinogenesis . 2013; 52 (supplement 1):87–95. doi: 10.1002/mc.22017. [ Cross Ref ]Wang S, Tao G, Wu D, Zhu H, Gao Y, et al. (2013) A functional polymorphism in MIR196A2 ...
hsa-miR-196a-5p overexpression is associated with MIR196A2 methylation and affects the malignant biological behavior of glioma hsa-miR-196a-5p is involved in tumorigenesis and progression; however, the driving factors for hsa-miR-196a-5p overexpression and its correlation with the ... SQ B,OQ...
Methods:A retrospective case-control study exploring the association of miR-146a, miR-196a2, miR-499, and miR-149 SNPs in 126 ALL patients and 126 healthy controls. Results:Of the tested variants, significantly lower minor allele frequencies (MAF) of miR-146a C-allele and higher MAF ...
A retrospective case-control study exploring the association of miR-146a, miR-196a2, miR-499, and miR-149 SNPs in 126 ALL patients and 126 healthy controls. Results Of the tested variants, significantly lower minor allele frequencies (MAF) of miR-146a C-allele and higher MAF frequency of mi...
目的探讨miR-146a和miR-196a2前体区遗传多态位点rs2910164 G>C和rs11614913 T>C与焦炉工遗传损伤的关联性。方法于2010年9月至10月,选取湖北省武汉市某焦化厂工龄在1年以上,无肿瘤,无吸烟习惯的焦炉作业工人,共575名。收集一般人口学资料并采集外周静脉血和尿液;采用胞质分裂阻滞试验计算外周血淋巴细胞的...
The present study aimed to evaluate the impact of miR-499 rs3746444, miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was done on 169 patients with pathologically confirmed ...
miR196a2基因rs11614913位点C/T等位基因分布差异具有统计学意义(P<0.05);CC组miR-146a mRNA,miR196a2 mRNA表达水平高于CIN组及对照组,CIN组高于对照组(P<0.05);ROC分析结果显示,外周血中miR-146a,miR196a2 mRNA诊断CC的曲线下面积(AUC)均>0.7.结论miR-146a和miR-196a2基因多态性可能是本地区高危型HPV感染女性...
MiR-196 a2 rs11614913 T/C基因多态性与类风湿关节炎遗传易感性的研究 来自 掌桥科研 喜欢 0 阅读量: 101 作者:王玉月,汪明杰,刘瑞平,周鑫叠 摘要: miRNA 组成的一系列非编码RNAs,通过集合目标mRNA 3′端,进而促进或者抑制目标 mRNA表达. 本研究中,我们采用以医院为基础的病例-对照研究,运用48-SNP体系...