A549和CHO三种细胞后进行荧光素酶活性分析,pCDNA3.1-miR196a2-C等位基因荧光素酶相对活性与pCDNA3.1-miR196a2-T等位基因相比均有显著降低(P<0.05);含不同基因型的化学合成的成熟miR-196a2探针与靶基因LSP1报告质粒共转染HEK293、A549和CHO三种细胞,miR-196a2-C等位基因荧光素酶活性与miR196a2-T等位基因相比也有...
miR.423在乳腺癌中的功能,本研究首先检测了miR.196a2SNP位点rsll614913 及miR.423SNP位点rs6505162在5对细胞系及114对组织中的突变情况。结果 显示:14%的组织中miR.196a2SNP位点rsll614913发生了体细胞突变,并且 成熟miR.196a2的表达与体细胞突变及临床病理指标组织学分级显著相关。 miR.423SNP位点rs6505162在...
hsa-miR-196a-5p overexpression is associated with MIR196A2 methylation and affects the malignant biological behavior of glioma hsa-miR-196a-5p is involved in tumorigenesis and progression; however, the driving factors for hsa-miR-196a-5p overexpression and its correlation with the ... SQ B,OQ...
Methods:A retrospective case-control study exploring the association of miR-146a, miR-196a2, miR-499, and miR-149 SNPs in 126 ALL patients and 126 healthy controls. Results:Of the tested variants, significantly lower minor allele frequencies (MAF) of miR-146a C-allele and higher MAF ...
A retrospective case-control study exploring the association of miR-146a, miR-196a2, miR-499, and miR-149 SNPs in 126 ALL patients and 126 healthy controls. Results Of the tested variants, significantly lower minor allele frequencies (MAF) of miR-146a C-allele and higher MAF frequency of mi...
The present study aimed to evaluate the impact of miR-499 rs3746444, miR-196a2 rs11614913, miR-149 rs2292832, and miR-146a rs2910164 polymorphisms on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was done on 169 patients with pathologically confirmed ...
目的:探讨携带有微RNA(microRNA,miRNA ,miR)-196b-5p的骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)来源的外泌体(exosomes)对结肠癌细胞耐药性的影响及其机制。 方法:分离收集BALB/c小鼠BMSCs并采用FCM法进行鉴定...
MiR-196 a2 rs11614913 T/C基因多态性与类风湿关节炎遗传易感性的研究 来自 掌桥科研 喜欢 0 阅读量: 101 作者:王玉月,汪明杰,刘瑞平,周鑫叠 摘要: miRNA 组成的一系列非编码RNAs,通过集合目标mRNA 3′端,进而促进或者抑制目标 mRNA表达. 本研究中,我们采用以医院为基础的病例-对照研究,运用48-SNP体系...
miRNA polymorphisms (miR-146a, miR-149, miR-196a2 and miR-499) are associated with the risk of coronary artery disease 来自 国家科技图书文献中心 喜欢 0 阅读量: 27 作者:JH Sung,SH Kim,WI Yang,WJ Kim,JY Moon,IJ Kim,DH Cha,SY Cho,JO Kim,KA Kim ...
miR-196a2 (rs11614913) polymorphism is associated with coronary artery disease, but not with in-stent coronary restenosisCoronary artery diseaseCoronary stentingMicroRNAPolymorphismRestenosisThe aim of the study was to evaluate the association of miRNA-146a G/C (rs2910164), and miRNA-196a2 C/T (...