tPtpn2 = 0.954, P = 0.3543; tPde10a = 0.3656, P = 0.7195. Unpaired Two-Tailed t- test; n.s., nonsignificant. (c) Western blot was performed to validate the result of the proteomics analysis. In 12- day-old mice cortex tissue, protein expression of the most up...
, 241–261,(2008). . Partial loss of psychiatric risk gene mir137 in mice causes repetitive behavior and impairs sociability and learning via increased pde10a., 1689–1703,(2018). Clin Genet, 435–443,(2011). (2015).
miR - 137在杂合子cKO小鼠中的部分缺失导致突触可塑性失调、重复行为以及学习和社交行为受损。转录组学和蛋白质组学分析显示,杂合敲除小鼠的miR - 137 mRNA靶磷酸二酯酶10a ( Pde10a )升高。用Pde10a抑制剂罂粟碱或Pde10a敲除物治疗可改善杂合子cKO小鼠观察到的缺陷。总之,我们的结果表明,miR - 137在出生后神...
通过整合蛋白质组、转录组、分子生物学、生物化学等方法,鉴定出miR-137的一个关键靶基因Pde10a。通过给小鼠注射Pde10a特异性抑制剂(papaverine)、或者短发夹RNA病毒(sh-Pde10a),杂合子的miR-137敲低小鼠的刻板重复行为、社交能力、学习记忆功能得到了很好的改善。该研究首次提供了miR-137缺失导致精神疾病的在体实验...