(hexokinase 2,HK2);miR-675-5p下调可增加PD-L1 mRNA稳定性并引起PD-L1积累,这一作用可能是通过与PD-L1的3'非翻译区(3'-untranslated region,3'-UTR)结合实现的,而HK2上调可促进有氧糖酵解并介导HLA-ABC下调.结论在HCC细胞中,EGFR-P38 MAPK途径可通过miR-675-5p上调PD-L1表达,通过HK2下调HLA-ABC表达....
英文名称:mmu-miR-675-5p antagomir品牌厂商性质产地货期价格 MedChemExpress (MCE) 生产商 美国 现货 ￥1800 性能特点 mmu-miR-675-5p antagomir 是一种经过特殊化学修饰的成熟miRNA的互补单链,全链进行甲氧基修饰,在5'端和3'端分别有2个和4个硫代骨架修饰,并在3'端连接有高亲和性胆 ...
H19和miR-675-5p的过表达逆转了槐耳提取物的抑制作用,而H19和miR-675-5p的水平降低使乳腺癌细胞对槐耳提取物敏感。因此,本研究表明,槐耳提取物通过H19/ miR-675-5p轴抑制乳腺癌进展。因此,槐耳提取物是用于乳腺癌临床治疗的有希望的治疗剂。 参考文献 Wang J, Wang X, Chen T, Jiang L, Yang Q. Huaier...
英文名称:mmu-miR-675-5p mimic 品牌厂商性质产地货期价格 MedChemExpress (MCE)生产商美国现货￥960 性能特点 mmu-miR-675-5p mimic 是一种化学合成的miRNA模拟物,能模拟内源性miRNA,上调miRNA活性,用于功能获得性(gain-of-function)研究。 在线咨询
此外,lncRNAH19/miR-675-5p/PFKFB3轴参与了对口腔CAFs糖酵解途径的促进,这可以通过荧光素酶报告系统检测和miRNA特异性抑制剂的治疗得到证实。本研究为了解口腔CAFs的糖代谢提供了一种新的途径,理论上为OSCC分子诊断提供了新的生物标志物,为抗肿瘤治疗提供了新的靶点。
P38 MAPKPD‐L1HLA‐ABCmiR‐675‐5pHexokinase‐2Hepatocellular carcinomaBackground Immunotherapy has been shown to be a promising strategy against human cancers. A better understanding of the immune regulation in hepatocellular carcinoma (HCC) could help the development of immunotherapy against HCC. The ...
Here we describe, for the first time, that miR675-5p, embedded in hypoxia-induced long non-coding RNA H19, plays a mandatory role in establishing a hypoxic response and in promoting hypoxia-mediated angiogenesis. We demonstrated,in vitroandin vivo, that miR675-5p over expression in normoxia ...
miR-9-5p, miR-675-5p, and miR-138-5p damage strontium and LRP5-mediated skeletal cell proliferation, differentiation, and adhesion, and induce cell apoptosis by targeting GSK3β, ATP8A2, and EIF4EBP1, respectively. Keywords: microRNA or miRNA; bone; strontium; cell proliferation; ...
miR-9-5p, miR-675-5p, and miR-138-5p damage strontium and LRP5-mediated skeletal cell proliferation, differentiation, and adhesion, and induce cell apoptosis by targeting GSK3β, ATP8A2, and EIF4EBP1, respectively. 展开 关键词: Article ...
First of all, we studied the influences on cell count of these three miRNAs. We seeded the same numbers of MC3T3-E1 cells (5 × 104cells/well) in six-well plates. The cells were transfected with miR-9-5p, miR-675-5p, and miR-138-5p mimics (40 nM). Every group contained triplicate...