然而,对于miR-422a在骨代谢中的作用和骨质疏松发生机制的影响尚未有明确的研究结果。 本研究旨在探究miR-422a在绝经后骨质疏松患者外周血单核细胞中的表达和功能,揭示其在骨代谢中的作用,并为骨质疏松的治疗和预防提供新的思路和实验基础。 二、研究内容和方法 首先,本研究将采集100例绝经后骨质疏松患者和100例...
结论miR-422a 可通过靶向KLK4蛋白的表达抑制宫颈癌细胞增殖、迁移和侵袭。关键词：宫颈肿瘤；激肽释放酶类；微RNAs ；HeLa 细胞；细胞增殖；细胞运动；细胞侵袭；miR-422a 中图分类号：R737.33文献标志码：A DOI ：10.11958/20210777 miR-422a targeting Kallikrein 4inhibits proliferation,migration and invasion ...
通过试剂盒从血浆中提取外泌体源性miRNA,再采用实时荧光定量聚合酶链反应(qRT-PCR)测定缺血性脑卒中不同时相(1,2,3和4 d)血浆外泌体源性miR-422a的表达变化,与对照组进行比较,通过ROC曲线评估其作为诊断标志物的价值,并采用单因素方差分析Games-Howell检验方法对不同分组中的血浆外泌体源性miRNA表达量进行比较...
Ectopic expression of miR-422a inhibited cell proliferation and tumor growth ability; inhibition of endogenous miR-422a, by contrast, promoted cell proliferation and tumor growth ability of CRC cells. MiR-422a directly targets 3′-UTR of the AKT1 and MAPK1, down-regulation of miR-422a led ...
CONCLUSION: Down-regulation of miR-422a may serve as an independent prognosis factor in CRC. MiR-422a functions as a tumor suppressor and regulates progression of CRC. Keywords:Colorectal cancer;MicroRNA;miR-422a;Prognosis;In vitrofunction ...
CCDC26 depletion enhanced miR-422a expression and MiR-422a inhibitor reversed CCDC26 knockdown-induced inhibition of thyroid cancer progression in vitro. CCDC26 upregulated EZH2 and Sirt6 expression by sponging miR-422a in thyroid cancer cells. Tumorigenicity analysis in nude mice revealed that CCDC...
结果:ciRS-7在胰腺癌相关成纤维细胞的外泌体中表达上调(P <0.05);CAFs释放的外泌体促进胰腺癌细胞糖酵解和增殖(P <0.05);敲降胰腺癌相关成纤维细胞ciRS-7的表达,其外泌体可抑制胰腺癌细胞糖酵解相关基因的表达(P <0.05);ciRS...
miR-422 a was significantly downregulated in NR tumors,in agreement with the increase in cell proliferation and adhesion induced by miR-422 a inhibition in vitro.Furthermore,we identified CD73/NT5 E oncogene as target of miR-422 a.Indeed,modulation of the endogenous level of miR-422 a ...
miR-494-3p and miR-422a can be used as non-invasive markers for predicting Hepatitis C Virus recurrence in patients after liver transplantation 来自 ResearchGate 喜欢 0 阅读量: 16 作者:T Agrawal,M Islam,M Choudhary,MS Kumar,SK Sarin ...
商标名称 明镜里 MJLMIR 国际分类 第11类-灯具空调 商标状态 商标注册申请 申请/注册号 45627211 申请日期 2020-04-21 申请人名称(中文) 佛山市明镜里智能家居有限公司 申请人名称(英文) - 申请人地址(中文) 广东省佛山市南海区里水镇大石工业区自编20号之二(住所申报) 申请人地址(英文) - 初审公告期号 -...