In addition, we demonstrated that therapeutic delivery of synthetic miR-4521 suppressed gastric carcinoma progression in vivo. Conclusions Our results suggest an important role for miR-4521 in regulating GC metastasis and hypoxic response of tumor cells as well as the therapeutic significance of this ...
而共转染RhoA质粒和可消除miR-133b对PC12细胞轴突生长的促进作用.第三部分:miR-133b的过表达促进了ERK1/2和Akt丝氨酸473位点的磷酸化,但是对p38的磷酸化没有影响,而且加入PI3K抑制剂LY294002和MAPK激酶MEK1抑制剂PD098059可以分别消除miR-133b对轴突生长的促进作用.和过表达miR-133b类似,抑制RhoA蛋白的表达也...