22、在其中一个实施例中,所述mir-1303和/或mir-4521在薄型子宫内膜患者的hucmsc中显著上调表达。 23、在其中一个实施例中,所述检测mir-1303和/或mir-4521表达水平的试剂包括引物。 24、在其中一个实施例中,所述检测mir-1303的引物为seq id no:1-2所示,所述检测mir-4521的引物为seq id no:3-4所示。 25...
MiR-4521 plays a tumor repressive role in growth and metastasis ofhepatocarcinoma cells by suppressing phosphorylation of FAK/AKTpathway via targeting FAM129AMunawar Ayeshaa , Abbasi Majid a , Dongting Zhao a , Frederick T. Greenaway d , Naimeng Yan b ,Qinglong Liuc , Shuqing Liu b, ⇑ ...
In addition, we demonstrated that therapeutic delivery of synthetic miR-4521 suppressed gastric carcinoma progression in vivo. Conclusions Our results suggest an important role for miR-4521 in regulating GC metastasis and hypoxic response of tumor cells as well as the therapeutic significance of this ...
而共转染RhoA质粒和可消除miR-133b对PC12细胞轴突生长的促进作用.第三部分:miR-133b的过表达促进了ERK1/2和Akt丝氨酸473位点的磷酸化,但是对p38的磷酸化没有影响,而且加入PI3K抑制剂LY294002和MAPK激酶MEK1抑制剂PD098059可以分别消除miR-133b对轴突生长的促进作用.和过表达miR-133b类似,抑制RhoA蛋白的表达也...