为了进一步证实miR200b-3p在SYDE1/ERK通路中的调控作用,我们将SYDE1质粒瞬时转染到miR200b-3p过表达细胞中,并将SYDE1 siRNA瞬时转染到miR200b-3p敲低细胞中并测量 P-RHOA、P62、P-ERK、LC3 和 LAMP1 的蛋白表达水平,结果提示 miR200b-3p 通过 SYDE1 影响 ERK 磷酸化来影响自噬水平(图 6F-I,图 S2G-H)...
1.一种mir-200b-3p在制备治疗子宫内膜癌的药物中的应用,其特征在于:所述的mir-200b-3p负调控子宫内膜癌细胞中fosl2的表达。 2.根据权利要求1所述的应用,其特征在于:所述的mir-200b-3p通过抑制fosl2的表达来抑制子宫内膜癌细胞的增殖、迁移或侵袭。 3.根据权利要求1所述的应用,其特征在于:所述的mir-200b...
是miR-200b-3p的作用靶点.荧光素酶报告显示Notch1是miR-200b-3p的直接作用靶点.通过WB和RT-PCR进一步验证了,消癌解毒方可显著降低了 HepG2细胞中Notch1的表达,而转染anti-miR-shRNA则逆转了消癌解毒方诱导的Notch1表达的降低.结论:(1)消癌解毒方高剂量组能有效地抑制肿瘤生长,且升高血液中miR-200b-3p的...
200b-3p can inhibit the cell migration in BxPC-3 and PANC-1 cells. miR-200b-3p can inhibit the EMT and oridonin can inhibit the expression of ZEB1, N-cadherin and fibronectin but not increase the expression of E-cadherin, while the cell adhesion molecules ICAM-1 and VCAM-1 were decreas...
bbe-miR-200b-3p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:bbe-miR-200b-3p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:bbe-miR-200b-3p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对...
Expression of miR-96-5p and miR-134-5p was lower in prostate cancer tissues compared to BPH. Levels of miR-96-5p, miR-134-5p, and 181b-5p negatively correlated with the Gleason score. Given further studies, miR-96-5p, miR-134-5p and especially miR-200b-3p and miR-181b-5p may ...
货号:dre-miR-200b-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:dre-miR-200b-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制...
Transcription factor ERG (erythroblast transformation-specific (ETS)-related gene) is essential in endothelial differentiation and angiogenesis, in which microRNA (miR)-200b-3p targeting site is expected by miRNA target prediction database. miR-200b is k
Eight microRNAs (miR-196b-5p, miR-183-5p, miR-200b-3p, miR-196a-5p, miR-193a-3p, miR-29c-3p, miR-33b-5p, and miR-200a-3p) were differentially expressed in medulloblastoma of adults and children. Analysis of the validation set confirmed that miR-196b-5p and miR-200b-3p were ...
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