进一步探索miR-200a-5p的功能时观察到,在细胞模型和硒缺乏症动物模型中,miR-200a-5p的高表达会诱发RIP3依赖型程序性坏死的发生.通过对缺硒诱导的这一程序性坏死的分子机制的研究发现,大量活性氧(ROS)的生成,RNF11负性调控的炎症反应以及MAPK通路之间的共同作用可能介导了这一程序性坏死的发生.有趣的是,当在...
tgu-miR-200a-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:tgu-miR-200a-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:tgu-miR-200a-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配...
miR-200a-5p RNF11 1. Introduction Selenium (Se) is an essential trace element for the internal environment in the body during homeostasis and pathogenesis [1]. The current issue of Se deficiency in the environment is attracting increasing attention globally, as this deficiency may lead to many...
miR-200a-3p和miR-30a-5p是HF患者预后的影响因素(Waldχ2=4.321～128.193,P<0.05);Kaplan-Meier生存分析结果显示,血清中miR-200a-3p和miR-30a-5p高表达患者3年生存率低于miR-200a-3p和miR-30a-5p低表达患者(均P<0.05).结论 HF患者血清中miR-200a-3p和miR-30a-5p表达水平显著升高,二者与HF的发生及患者...
Idiopathic pulmonary fibrosis (IPF) is a rapidly progressive interstitial lung disease of unknown pathogenesis with no effective treatment currently available. Given the regulatory roles of lncRNAs (TP53TG1, LINC00342, H19, MALAT1, DNM3OS, MEG3),miRNAs (miR-218-5p, miR-126-3p, miR-200a-3p,...
货号:gga-miR-200a-5p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:gga-miR-200a-5p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制...
Methods: A PA cell model induced by palmitic and oleic acids (2:1) was used to assess lipid accumulation via Oil Red O and Nile Red staining. mRNA levels of miR-200a-5p and lipid metabolism genes were measured with RT-PCR, and AMPK, p-AMPK, and SERCA2b...
miR-200a-5p augments cardiomyocyte hypertrophy induced by glucose metabolism disorder via the regulation of selenoproteins.doi:10.1002/jcp.27206Tianshu YangTianqi LiuChangyu CaoShiwen XuJohn Wiley & Sons, Ltd
《miR-200a-5p调节卵泡形成的分子机理研究》是依托同济大学，由张欢担任项目负责人的青年科学基金项目。中文摘要 哺乳动物原始卵泡库的大小决定了雌性生育期的长短，人类原始卵泡形成异常会导致原发性卵巢功能不全和不孕不育等疾病。作为广泛被研究的转录后调控因子，miRNA在生殖生物学中发挥着重要作用，但在卵泡形成过程...