进一步探索miR-200a-5p的功能时观察到,在细胞模型和硒缺乏症动物模型中,miR-200a-5p的高表达会诱发RIP3依赖型程序性坏死的发生.通过对缺硒诱导的这一程序性坏死的分子机制的研究发现,大量活性氧(ROS)的生成,RNF11负性调控的炎症反应以及MAPK通路之间的共同作用可能介导了这一程序性坏死的发生.有趣的是,当在...
miR-200a-5p RNF11 1. Introduction Selenium (Se) is an essential trace element for the internal environment in the body during homeostasis and pathogenesis [1]. The current issue of Se deficiency in the environment is attracting increasing attention globally, as this deficiency may lead to many...
tgu-miR-200a-5p qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:tgu-miR-200a-5p 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:tgu-miR-200a-5p 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配...
Cardiomyocytes hypertrophy is a compensatory form of heart disease characterized by increased size of cardiomyocytes. However, the link between cardiac hypertrophy and Se-specific microRNA (miRNA) remains to be characterized. In the current study, we established a miR-200a-5p mimic and an inhibitor...
Furthermore, microRNA (miR)-30a-5p and miR-200a-5p were observed to be upregulated in HGSOC, and function as direct negative regulators of FOXD1 by targeting its 3'-untranslated region. The present study also revealed that FOXD1 promotes p21 expression in a p53-independent manner. In ...
exogenous FOXD1 expression inhibited ovarian cancer cell growth in vivo. Furthermore, microRNA (miR)-30a-5p and miR-200a-5p were observed to be upregulated in HGSOC, and function as direct negative regulators of FOXD1 by targeting its 3'-untranslated region. The present study also revealed...
摘要 目的 探讨妊娠期高血压miR-26b、miR-15b、miR-204-5p、miR-200a表达水平及临床意义。方法 回顾性选取83例2022年1月至2023年1月承德市妇幼保健院收治的妊娠期高血压患者的临床资料作为病例...展开更多 Objective To investigate the expression and clinical significance of miRNA(miR)-26b,miR-15b,miR-204...
Given the regulatory roles of lncRNAs (TP53TG1, LINC00342, H19, MALAT1, DNM3OS, MEG3), miRNAs (miR-218-5p, miR-126-3p, miR-200a-3p, miR-18a-5p, miR-29a-3p), and their target protein-coding genes (PTEN, TGFB2, FOXO3, KEAP1) in the TGF-β/SMAD3, Wnt/β-catenin, focal ...
miR-200a-5pselenoproteinsSelenium and selenoproteins are identified as potential determinants in pathological cellular hypertrophy. Cardiomyocytes hypertrophy is a compensatory form of heart disease characterized by increased size of cardiomyocytes. However, the link between cardiac hypertrophy and Se﹕pecific ...