MiR-146a plays a pivotal role in repression of innate immunity, but its function in the intestinal inflammation is sort of controversy, and the genetic regulatory networks regulated by miR-146a in IBD has not been revealed. Methods: RT-qPCR was employed to detect the expressio...
NPR3microRNAThe pathogenesis of obesity-related metabolic diseases has been linked to the inflammation of white adipose tissue (WAT), but the molecular interconnections are still not fully understood. MiR-146a controls inflammatory processes by suppressing pro-inflammatory signaling pathways. The aim of...
Intestinal inflammation induced by chemical damage to the epithelium (DSS and TNBS models) induces miR-146a, but no effect is observed in the lymphocyte transfer model. Finally, we found that miR-146a expression is upregulated in purified IECs from villi vs. crypts. Our results indicate that ...
MiR-146a alleviates inflammation of acute gouty arthritis rats through TLR4/MyD88 signal transduction pathway European Review for Medical & Pharmacological SciencesCHEN, X.GAO, Q.ZHOU, L.WANG, Y.SUN, R.-R.ZHANG, Z.-Y.
acnes induces miR-146a, which can downregulate the production of IL-6, -8, and TNF-α in acne inflammation by inhibiting the TLR2/IRAK1/TRAF6/NF-κB and MAPK pathways. Graphical abstract Download: Download high-res image (247KB) Download: Download full-size image...
Objective: To investigate the effect of microRNA-146a (miR-146a) on inflammation of diabetic cardiomyopathy in mice. Methods: Twenty male C57BL/6 mice were randomly divided into control group and diabetic myocardial model group, with 10 rats in each group. The model group was...
The results suggest that miR-146a is a potential therapeutic target for reducing inflammation in REC through inhibition of TLR4/NF-??B and TNF??. Our study will contribute to understanding of diabetic retinal pathology, as well as providing important clues to develop therapeutics for clinical ...
miR-146a Mimics Attenuate Allergic Airway Inflammation by Impacted Group 2 Innate Lymphoid Cells in an Ovalbumin-Induced Asthma Mouse Model 来自 Semantic Scholar 喜欢 0 阅读量: 24 作者:S Han,C Ma,L Bao,L Lv,M Huang 摘要: Background:The prevalence of allergic asthma has increased dramatically....
Previous studies have demonstrated that miR-146a-5p negatively regulated the intrinsic immune and inflammatory responses, whether the miR-146a-5p-enriched exosomes possess the anti-inflammation effect remains unclear. This study aimed to investigate the effect of miR-146a-5p-enriched exosomes on M1 mac...
[7]Contreras J, Rao DS. MicroRNAs in inflammation and immune responses. Leukemia 2012;26:404-13. [8]Jang SY, Chae MK, Lee JH, et al. Role of miR-146a in the Regulation of Inflammation in an In Vitro Model of Graves' Orbitopathy. Investigative ophthalmology & visual science 2016;57:402...