探讨MicroRNA-146a(miR-146a)在大鼠青光眼滤过手术(Glaucoma Filtration Surgery,GFS)后减轻或改善癜痕化的作用及其机制。 方法 体外培养原代Tenon's囊成纤维细胞,经转化生长因子B1(transforming growth factor B1,TGF-B1)处理后进行mRNA表达谱...
et al. Circular RNA TUBD1 acts as the miR-146a-5p sponge to affect the viability and pro-inflammatory cytokine production of LX-2 cells through the TLR4 pathway. Radiat. Res. 193, 383–393 (2020). 29. Chen, L. et al. MicroRNA-146a protects against cognitive decline induced by ...
are essential for the induction of immune tolerance. Here, we investigated microRNA-146a (miR-146a), a miRNA that is widely expressed in Tregs and closely related to their homeostasis and function, with the aim of enhancing the function of Tregs by regulating miR-146a and then suppressing...
MIR146A的详细信息,包括基因名称,代码,染色体位置,相互作用关系和通路,简述为微RNA(miRNAs)是短(20-24核苷酸)非编码由既影响稳定性和mRNA的翻译参与基因表达的转录后调控在多细胞生物体的RNA。的miRNA通过RNA聚合酶II转录为加盖并聚腺苷酸化初级转录物的部分(PRI-
系统性红斑狼疮是一种具有极强遗传倾向的系统性自身免疫病,I型干扰素通路过度活化是其重要的分子表型。microRNA(miRNA)在维持免疫系统稳态中发挥重要作用。中科院上海生命科学研究院/上海交大医学院健康所分子风湿病学研究组的前期
miRNA-146a荧光成像DNA四面体中枢神经系统(CentralNervousSystem,CNS)对人体生命活动至关重要.血脑屏障(Blood-BrainBarrier,BBB)被认为是神经血管单元的一部分,包括脑微血管内皮细胞,周细胞,星形胶质细胞,神经元,小胶质细胞以及细胞外基质等.血脑屏障位于中枢神经系统脑微血管水平,是血液循环和脑交换的最大界面. 目前,...
小分子RNA(micro RNA)是一类内源基因非编码单链小RNA分子,可通过转录后抑制调节细胞的增殖、分化、凋亡及免疫应答等重要生命过程。miR146a是最早被发现参与调节免疫反应的miRNA,它的表达异常与自身免疫性疾病的发生与发展密切相关,在自身免疫性疾病的研究中受到广泛关注,研究miR146a在自身免疫性疾病的作用机制有助于其...
近年,microRNA(miRNA)在肿瘤发生、发展和转移中的作用日益受到关注[3],miRNA是一类长度为20~22核苷酸的非编码RNA,通过靶向调控基因表达,影响多种生物学过程,在多种疾病的发生发展中起到重要调控作用。已有研究[4-5]表明,miR-146a-...
et al. Circular RNA TUBD1 acts as the miR-146a-5p sponge to affect the viability and pro-inflammatory cytokine production of LX-2 cells through the TLR4 pathway. Radiat. Res. 193, 383–393 (2020). 29. Chen, L. et al. MicroRNA-146a protects against cognitive decline induced by ...
H. et al. Attenuation of inflammatory mediator production by the NF-kappaB member RelB is mediated by microRNA-146a in lung fibroblasts. Am. J. Physiol. Lung Cell Mol. Physiol. 304, L774–L781 (2013). Article CAS Google Scholar Kida, Y. et al. Interleukin-1 stimulates cytokines, ...