In the mouse model, microRNA-136-3p Agomir ameliorated alcohol-induced osteopenia, with the concomitant restoration of bone mass and type-H vessel formation. For the first time, this study demonstrated the pivotal role of microRNA-136-3p/PTEN axis in regulations of vascularization and bone ...
货号:chi-miR-136-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:chi-miR-136-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
biomarker; microRNA; mild TBI; miR-9-3p; miR-136-3p; plasma; severe TBI1. Introduction Traumatic brain injury (TBI) is defined as “an alteration in brain function, or other evidence of brain pathology, caused by an external force” [1]. Each year, approximately 69 million people world...
其发生机制与高糖皮质激素(而非咖啡因)通过编程亲代精子miR-142-3p高甲基化介导PPCE所致雄性子代大鼠肝脏脂代谢紊乱及代谢性炎症活化有关,并首次提出miR-142-3p是一个关键的脂代谢调节分子,可作为父源性NASH发生的早期干预靶标。
本发明公开了miR29a3p抑制物在制备神经干细胞向神经元分化的促进药物中的应用,属于生物医药技术领域.本发明采用miRNA抑制物对miR29a3p的表达进行下调,以miRNC作为对照,将携带有miR29a3p抑制物和对照miRNC的慢病毒分别感染神经干细胞后进行筛选,得到稳定低表达和正常表达miR29a3p的神经干细胞系,体外分化培养,观察两种情...
探寻miR-200a-3p作为结直肠癌的诊断及预后生物标志物的潜在价值 目的:阐明miR-200a-3p及下游靶基因程序性细胞死亡4(programmed cell death 4,PDCD4)在结直肠癌(colorectal cancer,CRC)诊断及预后的潜在价值.方法:从2017年1月至2019... 刘洁琼,姚雅俪,曹永清,... - 《重庆医科大学学报》 被引量: 0发表: 0...
miR-9a-3p, miR-136-3p, and miR-434-3p were identified as the most promising candidates at 2 days after lateral FPI. Digital droplet PCR (ddPCR) revealed 4.2-, 2.8-, and 4.6-fold elevations in miR-9a-3p, miR-136-3p, and miR-434-3p levels (p < 0.01 for all), respectively, ...
miR-136-3ptrophoblastThe precise molecular mechanism behind fetal growth restriction (FGR) is still unclear, although there is a strong connection between placental dysfunction, inadequate trophoblast invasion, and its etiology and pathogenesis. As a new type of non-coding RNA, circRNA has been shown...
RT-qPCR based validation was performed for the technically validated candidates (rno-miR-9a-3p, rno-miR-136-3p, and rno-miR-434-3p; see Results). Because the RNA used in this step was extracted from 50 µL plasma instead of 200 µL, and eluted to 30 µL instead of 14 µL,...
(Endoplasmic reticulum,ER)应激;OL-FS13通过激活Nrf-2途径加强抗氧化应激系统,发挥抗氧化应激功能,进而减轻ER应激损伤;OL-FS13神经保护作用中mi R-21-3p/CAMKK2轴起关键作用;OL-FS13通过激活CAMKK2/AMPK轴缓解能量应激;OL-FS13通过抑制mi R-21-3p激活CAMKK2/AMPK信号通路进而实现神经保护作用.【结论】本...