miR-134-3p金属蛋白酶解离素9细胞增殖凋亡迁移目的探究miR-134-3p是否通过靶向调控ADAM9/EGFR/AKT通路影响结肠癌细胞的存活和迁移.方法实时定量PCR检测正常结肠上皮细胞NCM460和结肠癌细胞SW480,HCT116和RKO中miR-134-3p的表达,Western免疫印迹检测上述细胞中ADAM9,EGFR和AKT的蛋白表达;miR-134-3p mimic/miR-134-...
Furthermore, miR-134-3p overexpression heightened GC apoptosis, while its knockdown reduced it. Importantly, miR-134-3p overexpression blocked the PI3K/AKT/mTOR axis, whereas its knockdown stimulated it. Overall, the outcomes of transfections with INHBA and miR-134-3p showed that, in sheep GCs,...
货号:mml-miR-134-3p 原价:￥4030 现价:￥3098.38节省:￥931.62 规格:1 kits 说明:mml-miR-134-3p 特异性茎环引物试剂盒 ￥615 产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过碱基互补配对的方式与靶基因的29’UTR区部分或完全互补,剪切靶基因的转录产物或者抑制转录...
[背景]研究表明铝暴露会导致miRNA-134-3p表达升高,与铝致学习记忆损害机制有关.但职业铝暴露工人外周血中miRNA-134-3p表达水平是否与血铝浓度存在关联性尚无报道.[目的]探讨职业铝暴露工人外周血铝浓度与miR-134-3p表达水平的关联性.[方法]采用整群抽样的方法选取山西某铝厂电解铝车间,氧化铝车间及热电车间的在岗男...
目的:探讨外周血单个核细胞(PBMCs)中miR-144-5p,miR-668-3p,miR-134-5p在儿童原发性免疫性血小板减少症(ITP)中的表达变化.方法:采用RT-qPCR检测25例ITP患儿和15例正常对照PBMCs中3种miRNAs相对表达量,Sysmex XE-5000全自动血细胞分析仪检测血小板计数及未成熟血小板分数(IPF%);分析miRNAs与血小板计数的相关性,...
Histochemistry and Cell Biology (2021) 155:423–433 https://doi.org/10.1007/s00418-020-01941-2 ORIGINAL PAPER miR‑96‑5p, miR‑134‑5p, miR‑181b‑5p and miR‑200b‑3p heterogenous expression in sites of prostate cancer versus benign prostate hyperplasia—archival ...
结果:ITP患儿组PBMCs中的mi R-144-5p和mi R-668-3p较对照组表达均上调,mi R-134-5p表达下调(均P<0.05)。mi R-144-5p和mi R-668-3p在急性ITP患儿组中表达量要高于慢性ITP患儿组(均P<0.05),且miR-144-5P(r=-0.802,P<0.001)和miR-668-3p(r=-0.753,P<0.001)的相对表达量与外周血小板计...
RIP实验证实circ_0120051与miR-144-3p之间具有明显结合作用。在mCFs中转染miR-144-3p可促进纤维化相关基因的表达,并有效逆转circ_0120051对mCFs纤维化表型的抑制作用。双萤光素酶报告基因实验证实miR-144-3p与Idh2的3’-UTR存在结合作用...
The aim of the study was to assess the level of expression of miR-96-5p, -134-5p, -181b-5p, -200b-3p in FFPE samples of prostate cancer, adjacent cancer-free tissue, and benign prostatic hyperplasia. Samples of 23 FFPE prostate cancer and 22 benign prostatic hyperplasias were dissected...
Taking together, we investigated the role of miR-545-3p in the process of HCC through regulating MT1M. 展开 关键词: miR-545-3p MT1M Hepatocellular carcinoma Invasion and migration DOI: 10.1016/j.biopha.2018.09.009 年份: 2018 收藏 引用 批量引用 报错 分享 ...