miR-129-5p属于miR-129家族成员之一,可通过下调SOX6减轻阿尔茨海默病大鼠的神经损伤与炎症反应[11];亦可通过Wnt/β-catenin信号通路靶向COL3A1,参与右美托咪定对新生大鼠缺氧缺血性脑损伤的神经保护作用[12]。有学者在自身免疫性脑脊髓...
Objective To investigate the mechanism of long non-coding RNA nuclear-enriched abundant transcript 1 (LncRNA-NEAT1) in inducing hepatocyte pyroptosis in acute liver injury through the regulation of the miR-129-5p/high mobility group box 1 (HMGB1) axis....
miR-129-5p has been suggested to play roles in Alzheimer’s disease, potentially involving the regulation of autophagy [51], neuroinflammation [52, 54, 55], and neuronal cell death [53,54,55] through targeting amyloid precursor protein (APP) [51], high-mobility group box 1 (HMGB1) [55]...
63细胞中miR-129-5p的表达量(P<0.05),且可抑制MG-63细胞的增殖和迁移(P<0.05),同时降低HMGB1的表达水平;转染miR-129-5p抑制物后可显著降低Saos-2细胞中miR-129-5p的表达量(P<0.05),且可增强Saos-2细胞增殖和迁移能力(P<0.05),同时提高HMGB1表达水平.结论 miR-129-5p可能通过HMGB1基因抑制骨肉瘤细胞增殖和...
miR-129-5p修饰骨髓间充质干细胞外泌体抑制心肌梗死小鼠心室重构 相关领域 微泡间充质干细胞外体炎症医学心功能曲线心肌纤维化骨髓癌症研究HMGB1心肌梗塞纤维化小RNA干细胞心脏纤维化细胞凋亡免疫学细胞生物学病理内科学生物心力衰竭生物化学基因 网址 http://dx.doi.org/10.1002/term.3268 ...
Down-regulating lncRNA KCNQ1OT1 relieves type II alveolar epithelial cell apoptosis during one-lung ventilation via modulating miR-129-5p/HMGB1 axis induce... Objective Endothelial glycocalyx (EG) maintains vascular homeostasis and is destroyed after one-lung ventilation (OLV)-induced lung injury. Lo...
HMGB1ApoptosisInflammatory responseMicroRNAs are dysregulated in sepsis. Acute lung injury is a progressive syndrome during sepsis. However, the role of miR-129-5p in the development of acute lung injury induced by sepsis remains unclear.#The acute lung injury of sepsis model was established by ...
miR-129-5p与HMGB1的关系.结果 四氯化碳处理细胞后,肝细胞中ALT和AST水平显著增加,IL-1β和IL-18表达水平升高,细胞活性下降,NEAT1表达升高,miR-129-5p表达抑制,差异均有统计学意义(P<0.05);干扰NEAT1后,肝细胞中ALT,AST,IL-1β,IL-18水平下降,miR-129-5p表达显著增加,差异均有统计学意义(P<0.05);...
129-5p过表达或下调HMGB1表达后,TNF-α诱导的MH7A细胞上清液中IL-6,IL-1β水平明显降低(P<0.05);并且,miR-129-5p低表达可明显逆转10μmol/L塞来昔布对TNF-α诱导的MH7A细胞上清液中IL-6,IL-1β水平抑制作用.结论 塞来昔布可抑制TNF-α诱导MH7A细胞炎症因子分泌,其作用机制可能与调控miR-129-5p/HMGB1有关...
目的:探讨miR-129-5p 通过调控高迁移率族蛋白B1 基因(high mobility group box 1,HMGB1)影响乳腺癌MCF-7 细胞对紫杉醇(paclitaxel,PTX)的敏感性.方法:采用脂质体转染技术将miR-129-5p mimics,HMGB1 小干扰RNA(si-HMGB1)分别转染入MCF-7 细胞,用PTX刺激培养细胞后,用实时荧光定量PCR检测转染后MCF-7 细胞miR-...