有学者在自身免疫性脑脊髓炎相关癫痫模型中发现,miR-129-5p可通过抑制TLR4/NF-κB信号通路靶向下调HMGB1表达而减轻大鼠神经元损伤[13]。另有学者在氧—葡萄糖剥夺诱导的海马神经元细胞以及大脑中动脉闭塞小鼠中发现miR-129-5p表达下调,m...
Thus, we hypothesize human USCs inhibits the expression and releasing of HMGB1 in injury renal tubular cells probably through the release of miR-129-5p and subsequently inhibit infiltration of inflammatory cells. FIGURE 1. The protective effect of human urine-derived stemcells on ...
miR-129-5p has been suggested to play roles in Alzheimer’s disease, potentially involving the regulation of autophagy [51], neuroinflammation [52, 54, 55], and neuronal cell death [53,54,55] through targeting amyloid precursor protein (APP) [51], high-mobility group box 1 (HMGB1) [55]...
将miR-129-5p模拟物和抑制物分别转染到miR-129-5p表达量较低和较高的骨肉瘤细胞株中,RT-PCR检测转染效率.转染成功后分别用CCK-8法,划痕实验和Transwell迁移实验检测OS细胞株的增殖和迁移能力;Western blot检测转染后OS细胞株中HMGB1的表达.结果 miR-129-5p在OS细胞中的表达低于正常成骨细胞(P<0.05),HMGB1在OS...
ZHANG等[16]研究显示,内皮细胞中过表达miR-126可通过抑制HMGB1来降低炎性细胞因子,包括TNF-α、ROS和NADPH氧化酶活化,从而减轻炎症反应。研究显示,miR-126表达可通过与SPRED1基因、磷酸肌醇3-激酶调节亚基2(PIK3R2)和血管细胞黏附分子-1(V...
Exosomes derived from miR-129-5p modified bone marrow mesenchymal stem cells represses ventricular remolding of mice with myocardial infarction miR-129-5p修饰骨髓间充质干细胞外泌体抑制心肌梗死小鼠心室重构 相关领域 微泡间充质干细胞外体炎症医学心功能曲线心肌纤维化骨髓癌症研究HMGB1心肌梗塞纤维化小RNA干...
miR-129-5p对抗心室重构治疗短期预后的预测效能.结果抗心室重构治疗2个月后有效(显效+有效)62例,为有效组;无效25例,为无效组.治疗2个月后有效率为71.3%.两组患者治疗前miR-129-3p,miR-129-5p表达水平比较,差异均无统计学意义(均P>0.05);与治疗前比较,两组患者治疗1,2个月后miR-129-3p,miR-129-5p表达...
mir-129-5p attenuates irradiation-induced autophagy and decreases radioresistance of breast cancer cells by targeting HMGB1. Med Sci Monit. 2015;21:4122–9. Article PubMed PubMed Central Google Scholar Kong LM, Liao CG, Zhang Y, Xu J, Li Y, Huang W, et al. A regulatory loop involving ...
摘要: 目的 探讨阿司匹林(Asp)通过调节微RNA-340-5p(miR-340-5p)/高迁移率族蛋白1(HMGB1)/Toll样受体4(TLR4)通路对大鼠心肌缺血/再灌注(I/R)损伤的影响。方法将雄性SD大鼠分为假手术(Sham)组(开胸不结扎)、I/R组(构建I/R损伤模型)、Asp预处理(I/R+Asp)组(Asp预处理7d+造模)、I/R+Asp+in-miR-34...
miR-574-5p is an unusual microRNA (miRNA) that is often upregulated or downregulated following exposure to irradiation or toxic chemicals; bacterial, parasitic or viral infection; and a variety of other disease conditions. Canonically, miR-574-5p epigene