结果显示miR-1271-5p在胃癌肿瘤组织中表达下调,且miR-1271-5p低表达与肿瘤浸润程度、淋巴结转移和肿瘤分期等不良临床特征有关,miR-1271-5p高表达患者的生存期较低表达患者延长,与上述研究结果一致,提示miR-1271-5p可能在胃癌的发生和进展中...
相比于mimics NC组,mimics miR-1271-5p组细胞活力降低,细胞凋亡率增加,F13A1表达显著降低(P<0.05),inhibitors miR-1271-5p组F13A1表达显著升高(P<0.05)。相对于mimics miR-1271-5p组,过表达F13A1逆转miR-1271-5p对OSCC的抗增殖和促凋亡作用(P<0.05)。结论:miR-1271-5p靶向F13A1基因抑制OSCC细胞增殖,促进细胞...
We conclude that miR-1271-5p has the potential to drive progression of hormone-dependent disease and that the use of specific inhibitors of miR-1271-5p may have therapeutic potential in prostate cancer.Kalofonou, FoteiniLeach, Damien A.
Prediction of miRNA for key genes. (A) The miRNA-mRNA interaction network of candidate genes. Significant prognostic values of has-miR-1271-5p on the overall survival of Colon cancer patients by (B) ENCORI and (C) OncoLnc database. (D) The binding sequence between hsa-miR-1271-5p and P...
miR?1271?5p inhibits cell proliferation and induces apoptosis in acute myeloid leukemia by targeting ZIC2.doi:10.3892/mmr.2018.9680... Xiaohe,Chen,Shouhang,... - 《Molecular Medicine Reports》 被引量: 0发表: 2018年 Long non-coding RNA HULC promotes bladder cancer cells proliferation but inhibits...
It was also observed that RP11-619L19.2 was reciprocally repressed by miR-1271-5p. Of note, miR-1271-5p negatively regulated CD164 expression by directly targeting the 3′-untranslated region of CD164. Overexpression of CD164 reversed the antimetastatic activity of RP11-619L19.2 knockdown in CC...
干预后,采用HE染色法和透射电镜观察各组兔膝关节软骨组织形态和软骨细胞超微结构;TUNEL法检测各组兔膝关节软骨细胞凋亡水平;实时荧光定量PCR法检测各组兔膝关节软骨组织CircSERPINE2,miR-1271-5P,ERG mRNA表达.结果:干预后,与正常组比较,模型组Lequesne MG行为学评分升高(P<0.01);与模型组和假针刀组比较,针刀组...
Overall, LINC02381 exerts carcinogenic effects in BC by the miR-1271-5p/FN1 axis to activate PI3K/AKT pathway.doi:10.1002/mc.23375S.HuangP.HuangH.WuS.WangG.LiuMol CarcinogMolecular carcinogenesis
Methods Quantitative real-time polymerase chain reaction (qRT-PCR) was carried out to determine the expression levels of circ_0000043, microRNA-1271-5p (miR-1271-5p) and catenin delta 1 (CTNND1). 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and flow cytometry ...
HDAC9 was identified as a direct target of miR-1271-5p. HDAC9 overexpression or miR-1271-5p knockdown decreased the effect of ICA on ABCA1 and ABCG1 expression as well as inflammatory response. Taken together, these results suggest that ICA can suppress lipid accumulation and ...