miR-191-5pSATB1子痫前期上皮-间质转化滋养层细胞目的 探讨miR-191-5p靶向调节AT富集序列特异性结合蛋白1(SATB1),对子痫前期(pre-eclampsia,PE)滋养层细胞上皮-间质转化(epithelial-mesenchymal transition,EMT)及细胞迁移的影响.方法 收集滋养层细胞系HTR-8/SVneo及人绒毛膜癌细胞系JEG-3,JAR.分组转染后qRT-PCR...
Objective The aim of this study was to investigate the specificity of circulating microRNAs: miR-191-5p, miR-128-3p, miR-24-3p, and miR-376c-3p in MS and evaluate their association with disease activity and disability progression. Methods The expressions of circulating miRNAs were studied in ...
(3)成功通过数据库挖掘并在外泌体中验证了牙周膜干细胞外泌体高表达miR-100-5p.通过体外实验明确了miR-100-5p以及外泌体miR-100-5p可以促进细胞的成骨分化.成功的通过数据库预测并验证了miR-100-5p的靶基因为mTOR.结论:牙周膜干细胞外泌体miR-100-5p可以通过mTOR调节正畸移动牙齿局部牙槽骨的改进,抑制正畸...
第一部分,miR-885-5p在原发性肝癌转移中作用机制的研究 背景:目前,肝癌是世界第六大肿瘤,在我国致死率位居第三.由于肝癌患者早期症状不是很明显,很多肝癌患者发现一般为晚期.肝癌对化疗表现为较强的耐受性.所以探索有效的生物标志物和生物治疗靶点对临床治疗肝癌具有重要意义. miR-885-5p是由miR-885的5'端剪切而...
The expression of serum miR-191-5p and miR-101-3p was related to TNM stage, lymph node metastasis, depth of invasion and differentiation of gastric cancer (P<0.05). The 3-year OS rate of gastric cancer patients with low expression of miR-191-5p was...
In contrast, siRNA-or miR-191-5pinduced EGFR downregulation or EGFR inhibitor boosts IFN-I signaling, reducing viral replication. Notably, this miRNA alleviates the suppressive effect of EGF on IFN-I signaling, underscoring its regulatory function. Further investigation revealed...
miR-191-5p内皮细胞层通透性TJP1目的探讨宫颈癌细胞分泌的外泌体miR-191-5p对血管内皮细胞层的通透性影响,为肿瘤血管相关的基因靶点研究提供理论依据.方法提取并鉴定宫颈癌细胞(SiHa/HeLa)培养上清来源的外泌体.将宫颈癌细胞源外泌体与人脐静脉内皮细胞(HUVEC)共培养,检测外泌体的摄取.跨内皮电阻(TEER)...
Taken together, our results indicate that circulating hsa-miR-323b-5p could be a promising serum biomarker for the diagnosis of critical limb ischemia in type 2 diabetic patients. 展开 关键词: Critical Limb Ischemia (CLI) T2DM Patients Type 2 Diabetes Mellitus (T2DM) Peripheral Artery Disease (...
miR-191-5pmiR-21-5pmiR-320a体外受精抗氧化全世界大约10%~15%的育龄夫妇都面临不孕不育难题.其中,40%~50%的不孕不育是由男性因素导致的[1].随着辅助生殖技术的不断发展,体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)技术已经成为临床上不孕不育治疗的主要途径.体外移植前的胚胎发育...
MiR-191-5p Attenuates Tau Phosphorylation, Aβ Generation, and Neuronal Cell Death by Regulating Death-Associated Protein Kinase 1Download: Download high-res image (122KB) Download: Download full-size imageLong WangXindong ShuiMi ZhangYingxue Mei...