目的探讨miR-3127-5p对三结构域蛋白家族28(TRIM28)的靶向作用以及对直肠癌细胞增殖,迁移和侵袭能力的影响.方法实时荧光定量PCR(RT-qPCR)和蛋白质印记(Western blot)检测直肠癌组织中miR-3127-5p和TRIM28的表达水平.将直肠癌细胞SW1463分为miR-NC,miR-3127-5p,si-NC,si-TRIM28,miR-3127-5p+pcDNA,miR-3127-...
As a result, we found that microRNA‐3127‐5p promotespSTAT3 to induce the expression ofPD‐L1; microRNA‐3127‐5p promotesSTAT3 phosphorylation through suppressing autophagy, and autophagy could retainepSTAT3 into the nucleus in miRNA‐3127‐5p knocked cells, and immune escape induced by ...
Reduced miR-3127-5p expression is associated with a higher Ki-67 proliferation index and unfavorable prognosis in NSCLC. Overexpression of miR-3127-5p significantly reduced NSCLC cells proliferation, migration, and motility in vitro and in vivo. The oncogene ABL1 was a direct miR-3127-5p target,...
Reverse: 5′-CTCTACAGCTATATTGCCAGCCAC-3′; MiR-3127-5p, Forward: 5′-ATCAGGGCTTGTGGAATGG-3′, Reverse: 5′-CTCTACAGCTATATTGCCAGCCAC-3′; MiR-548ar-3p, Forward: 5′-TAAAACTGCAGTTATTTTTGCGG-3′, Reverse: 5′-CTCTACAGCTATATTGCCAGCCAC-3′; MiR-548az-3p, Forward: 5′-AAAAACTGCAA...
采用实时荧光定量聚合酶链反应检测癌组织与癌旁组织中miR-770-5p、ZWINT表达,比较不同临床特征患者miR-770-5p、ZWINT差异;根据不同miR-770-5p、ZWINT表达程度分为miR-770-5p高表达组( n=65)、miR-770-5p低表达组( n=50),ZWINT高表达组( n=69)、ZWINT低表达组( n=46),比较不同组别患者预后情况。根据...
molecular mechanism of miR-1271-5p in tumorigenesis. In ovarian cancer, miR-1271-5p targetsE2F5which inhibits the mTOR signaling pathway, and as a result, growth of cancer cells was suppressed80. It was also suggested that miR-1271-5p binds toTIAM1to inactivate the Notch signaling pathway to...
Long noncoding RNA LINC00284 facilitates cell proliferation in papillary thyroid cancer via impairing miR-3127-5p targeted E2F7 suppression Article Open access 26 June 2021 METTL14 promotes tumorigenesis by regulating lncRNA OIP5-AS1/miR-98/ADAMTS8 signaling in papillary thyroid cancer Article Ope...
demonstrated that gain-of-function of miR-195-5p in colonic epithelial cell lines decreased the CLDN2 levels. This modulation, in turn, downregulated claudin-1 (CLDN1) expression at protein level but not that of occludin. Our data support a previously unreported role of miR-195-5p in ...
2010;70:3119–3127. doi:10.1158/ 0008-5472.CAN-09-4250 22. Li S, Zeng A, Hu Q, Yan W, Liu Y, You Y. miR-423-5p contributes to a malignant phenotype and temozolomide chemoresistance in glioblastomas. Neuro Oncol. 2017;19:55–65. doi:10.1093/neuonc/ now129 23. Stiuso P, Potenza...
Long non-coding RNA HOTAIR function as a competing endogenous RNA for miR-149-5p to promote the cell growth, migration, and invasion in non-small cell lung cancer. Front Oncol. 2020;10: 528520. Article Google Scholar Liu XH, Sun M, Nie FQ, Ge YB, Zhang EB, Yin DD, Kong R, ...