更重要的是,来源于GC-M1巨噬细胞的外泌体表现出更高的调节BMSCs成脂分化的能力,这是由miR-1a-3p介导的。在体内和体外,miR-1a-3p通过靶向Cebpz促进BMSCs的成脂分化,并在GA-ONFH的发生和进展中发挥重要作用。 糖皮质激素相关性股...
在FAN1敲除的HEK293T细胞中,3‘-UTR荧光素酶报告载体分析显示miR-124-3p导致15AM2单倍型的活性轻度下降,而以剂量依赖的方式显著降低了非15AM2单倍型的荧光素酶活性(图2F)。此外,miR-124-3p对非15AM2单倍型的影响被其抑制剂所消除(图...
Herpud1 was regulated by miR-9-3p in glioma cells and tissues and was identified as a miR-9-3p target with luciferase reporter assays. Glioma cells transfected with miR-9-3p mimics or HERPUD1-RNAi had more apoptotic cells than them in control after induced by H2O2. Our results indicated...
Resumption of miR-409-3p expression attenuated OS cell proliferation and invasion. Additionally, based on informatics analyses, we predicted that zinc-finger E-box-binding homeobox-1 (ZEB1) is a possible target of miR-409-3p. This hypothesis was confirmed using luciferase reporter assays, reverse ...
molecules Article Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells Sheng-Nan Lo 1,2, Chun-Wei Wang 1,2, Yueh-Shieh Chen 1, Chiung-Chiao Huang 1, Tian-Shung Wu 3, Lih-Ann Li 4, I-Jung Lee 5 and ...
研究表明,miR-29b-3p能够靶向调控DNMT3A。例如,在膀胱癌的研究中发现,miR-29b-3p可能通过抑制其靶基因DNMT3A来促进膀胱癌对于丝裂霉素的耐受。在非小细胞肺癌的研究中,也发现了miR-29b-3p靶向调控DNMT3A以及其他相关基因(如PTEN、PI3K、Akt等),参与EGFR-TKI获得性耐药的机制。 总之,miR-29b-3p与DNMT3A的相互作...
bdi-miR5174e-3p.1 qPCR试剂盒 分类:microRNA qPCR Kits 品牌:BioTNT 货号:bdi-miR5174e-3p.1 原价:￥4030 现价:￥3098.38 节省:￥932 规格:1 kits 说明:bdi-miR5174e-3p.1 特异性茎环引物试剂盒 ￥615产品参数 ---说明书下载--- microRNAs(miRNAs)是一类长度约19~24nt的非编码单链RNA,通过...
Echinops latifolius Polysaccharide B Ameliorates Glucose and Lipid Metabolism Disorder in Insulin Resistance HepG2 Cell through miR-494-3p/FOXO1/PGC1α Signaling Pathway 引用 收藏 分享 摘要 目的:探讨蓝刺头多糖B对棕榈酸诱导的HepG2胰岛素抵抗的抑制作用及可能机制。方法:MTT法检测蓝刺头多糖B对HepG2细胞...
The results of this study suggested the potential value of miR5083p and CCNA2 as prognostic indicators and therapeutics for ovarian cancer. 展开 关键词: microRNA-508-3p proliferation metastasis CCNA2 MMP7 ovarian carcinoma DOI: info:doi/10.3892/ijo.2020.5055 年份: 2020 ...
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