In this study, we found that circCCNB1 promoted the processing and generation of miR-7-1-3p and miR-15b-5p by binding to NF90, thereby inhibiting VM in NPC. Furthermore, circCCNB1 may become a potential therapeutic target for anti-angiogenic therapy in NPC. 2 Materials and methods 2.1 ...
更重要的是,来源于GC-M1巨噬细胞的外泌体表现出更高的调节BMSCs成脂分化的能力,这是由miR-1a-3p介导的。在体内和体外,miR-1a-3p通过靶向Cebpz促进BMSCs的成脂分化,并在GA-ONFH的发生和进展中发挥重要作用。 糖皮质激素相关性股...
miR-381-3p属于抑癌分子,其不仅影响肿瘤细胞的增殖过程,还对神经干细胞的增殖分化进行调控。BDNF属于脑源性神经营养因子,PI3K/AKT信号通路参与多种肿瘤细胞的生物学过程,本研究发现沉默miR-381-3p可抑制BDNF/pERK和PI3K/AKT/EMT信号通路...
miR-let-7c-3p/Egr-1的靶向调节TGF-β1/SMAD通路的作用,以及该信号轴在白血病细胞定向单核巨噬细胞分化中的作用.方法:利用PMA诱导人慢性髓系白血病细胞K562向单核/巨噬细胞方向分化,通过Wright-Gimesa染色,流式细胞术及周期检测各项分化指标;用RT-PCR,qRT-PCR和WB检测分化前后Egr-1的表达变化,q-PCR检测miR-...
Meanwhile, the discovery of that the expression level of miR-491-3p was inversely correlated with that of ABCB1 and Sp3 in HCC cell lines and clinical samples pointed out the possibility of miR-491-3p in clinical use. In summary, our results reveal a pivotal role of miR-491-3p in the ...
摘要: 目的 探讨miR-302b-3p靶向SQSTM1调控乳腺癌MCF7细胞的自噬.方法 运用TargetScan在线分析miR-302b-3p与SQSTM1的相关性;将SQSTM1的3'UTR构建进PMIR-RB-REPORT质粒,利用luciferase assay检测miR-302b-3p是否靶向调控SQSTM1;用R... 查看全部>>
molecules Article Berberine Activates Aryl Hydrocarbon Receptor but Suppresses CYP1A1 Induction through miR-21-3p Stimulation in MCF-7 Breast Cancer Cells Sheng-Nan Lo 1,2, Chun-Wei Wang 1,2, Yueh-Shieh Chen 1, Chiung-Chiao Huang 1, Tian-Shung Wu 3, Lih-Ann Li 4, I-Jung Lee 5 and ...
rs3512通过改变miR-124-3p的靶向序列,导致携带替代等位基因的患者FAN1表达水平相对于高于携带参考等位基因的患者,而且FAN1的表达与CAG扩增相关,可能与改变了FAN1和错配修复蛋白之间的竞争平衡有关,证明了miRNA对重复不稳定性的调节和对HD...
Resumption of miR-409-3p expression attenuated OS cell proliferation and invasion. Additionally, based on informatics analyses, we predicted that zinc-finger E-box-binding homeobox-1 (ZEB1) is a possible target of miR-409-3p. This hypothesis was confirmed using luciferase reporter assays, reverse ...
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