small-vessel diseasevascular cognitive impairmentwhite matter hyperintensitiesIschemic cerebral small-vessel disease accounts for a third of acute cerebral ischemic events and contributes to the development of cognitive decline and dementia. Cerebral small-vessel disease can be visualized on MRI studies as ...
Studies performed mainly in young athletic populations shortly after the initial infection recorded subtle myocardial inflammatory changes, non-ischemic myocardial scarring and pericarditis10,11,12,13. To address the uncertainties of the pathophysiology and its relation to symptoms, we conducted serial ...
Small Vessel Cerebrovascular Pathology Identified by Magnetic Resonance Imaging Is Prevalent in Alzheimer's Disease and Mild Cognitive Impairment: A Potent... magnetic resonance imagingneuropsychological testingsmall vessel pathologyThere is evidence that Alzheimer's disease (AD) has significant cerebrovascular...
Structural retinal changes in cerebral small vessel disease Article Open access 03 June 2022 Introduction Presently, the pathogenesis of cerebral small vessel disease (SVD) in humans is not completely understood, in part due to the difficulty in imaging in vivo the cerebral microvasculature. SVD is...
Quantification of Cerebral Small Vessel Disease Imaging markers of SVD were assessed on 3T MRI (Siemens; acquisition parameters in eAppendix of Supplement 1) according to the Standards for Reporting Vascular Changes on Neuroimaging (STRIVE) guidelines.14 CMB were assessed on 3T susceptibi...
that a significant portion of the variation in the DSOA score could be attributed to psychosocial stressors, specifically negative life events and adverse childhood experiences3. This suggests that these distress symptoms are more likely driven by psychosocial factors rather than changes in the immune ...
Ischemic brain lesions associated with hypertension (HTN). HTN induces atherosclerosis of major extracranial and intracranial arteries, which could lead to major infarcts. HTN causes both microbleeds and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar ...
lead to small vessel damage, lead to leukoar aiosis or asymptomatic cerebral infarction, and leukoaraiosis and asymptomatic cerebral infarction are important risk factors for cognitive impairment.50 Lu et al51 found that hyperhomocysteinemia promoted the Figure 1 (A) Shows scatterplot for MMSE...
have been described3. Impaired cerebral glucose metabolism37, mitochondrial dysfunction, and increased oxidative stress have all been observed8. In addition to neurodegenerative brain changes, dementia is frequently associated with vascular pathologies such as small vessel disease (multiple or single infarcts...
Thoresen M, Whitelaw A 2000 Cardiovascular changes during mild therapeutic hypothermia and rewarming in infants with hypoxic-ischemic encephalopathy. Pedi- atrics 106:103–111 38. Azzopardi D, Robertson NJ, Cowan FM, Rutherford MA, Rampling M, Edwards AD 2000 Pilot study of treatment with whole ...