Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TB
This does not exclude the possibility that more subtle types of vascular disease, such as microvascular damage or blood-brain barrier dysfunction, contribute to Aβ deposition.46Cerebrovascular disease is highly prevalent in the elderly population. In this study of clinically normal to mildly demented...
No other retinal measure was associated with SVD. Reduced fractal dimension, a measure of vascular complexity, is related to SVD imaging features in older people. The results provide some support for the use of the retinal vasculature in the study of brain microvascular disease....
Coronary microvascular dysfunction (CMD) may be a manifestation of systemic small vessel disease, including the brain. The prevalence of cognitive impairment in CMD patients is poorly understood.To assess the prevalence of cognitive impairment in patients with CMD.Between April 2018-March 2020, we enr...
Ischemic brain lesions associated with hypertension (HTN). HTN induces atherosclerosis of major extracranial and intracranial arteries, which could lead to major infarcts. HTN causes both microbleeds and macrobleeds and is the main pathogenetic factor for small vessel disease responsible for lacunar ...
However, the decline in sleep quality is also associated with an increase in beta amyloid deposits (a hallmark of AD) leading to faster disease progression51,57. Increased beta amyloid levels in the brain impair slow-wave sleep leading to sleep problems58,59, thus sleep problems might be a ...
Vascular Vascular NCD is a result of cerebrovascular diseases (e.g., infarcts, strokes, microvascular disease) Any age 0.2% in 65–70 years old, 16% in people >80 Common features include impaired complex attention and frontal-executive function. Other functional impairments may occur depending on...
Aphasia: Aphasia can be a troubling and even frustrating condition in which a person has difficulty comprehending or expressing language. It typically results from a brain injury, such as a stroke or a trauma. Answer and Explanation:1 Mild aphasia is a loosely used term to describe cases of ...
Serum biomarkers are promising tools for evaluating patients following traumatic brain injury (TBI). However, their relationship with diffuse histopathology remains unclear. Additionally, translatability is a focus of neurotrauma research, however, studi
Oxygen enriched air may increase oxygen pressure in brain tissue and have biochemical effects even in subjects without lung disease. Consistently, several studies demonstrated that normobaric oxygen treatment has clinical benefits in some neurological conditions. This study examined the efficacy of normobaric...