Chronic microvascular white matter ischemic change (WMIC) has been shown to be associated with acute brain infarction in the general population. WMIC has also been shown to be an independent predictor of non‐f
2a). After exposure to CoCl2 or OGD, the proliferation of brain microvascular endothelial cells (BMECs) was increased with enhanced apoptosis by the quantification of EdU-positive and TUNEL-positive cells (Fig. 2b, c). ZO-1 and Claudin-5 in the immunostaining were both fractured at the ...
What is microvascular ischemic brain disease? What is the pathogenesis of rheumatoid arthritis? What is myasthenia gravis with exacerbation? What neurological disorders can be seen on an MRI? What is athetoid cerebral palsy? What is rare macular edema?
Conclusions We demonstrated that EPC-CM protected the brain from chronic ischemic injury and promoted functional recovery through MIF-mediated AKT pathway. These findings suggest EPC-CM holds potential as a novel cell-free therapeutic approach for treating CCI through the actions of MIF.Introduction...
Indeed, AD patients show significantly worse cognition when they present chronic microvascular ischemic lesions, such as white matter hyperintensities7,8. One may hypothesize these changes derive from comorbid white matter dysfunction, which may affect brain function by interfering with inter-regional ...
The intrahepatic microvascular unit is made up of several discrete units, including portal venules, hepatic arterioles, sinusoids, central venules, and lymphatics. The cellular elements in these structures include endothelial cells, smooth muscle cells, and in the sinusoid, pericyte-like hepatic stella...
Ischemia triggers retinal remodeling, where the neurovascular interactions between neurons, glial cells, and microvascular cells within the NVU create an environment that supports tissue recovery [32]. Given that multicellular crosstalk within the local vascular networks and the neurons they supply is ...
to ischemic damage. As a result, CCI primarily impacts cognitive functions, including deficits in memory and learning [3,4], and can also contribute to motor dysfunction, mood disturbance, and eventually, vascular dementia or neurodegenerative conditions like Alzheimer’s disease (AD) [2,5,6,7]...
These Thbs4hi astrocytes migrate to the injured cortex following ischemic injury in mice and help to mitigate microvascular hemorrhage into the brain parenchyma [173]. Moreover, Thbs4−/− mice exhibit dysfunctional SVZ astrogenesis and abnormal glial scar formation in addition to extensive, ...
Hypertension and white matter lesions are independently associated with apathetic behavior in healthy elderly subjects: the Sefuri brain MRI study. Hypertens Res 2009; 32: 586–590. 34 Knopman DS. Invited commentary: Albuminuria and microvascular disease of the brain–a shared pathophysiology. Am J...