What is microvascular ischemic brain disease? What are the symptoms of microvascular brain disease? What neurological disease causes the brain to shrink? What is chronic traumatic encephalopathy? What are the types of neurodegenerative disease?
Chronic microvascular white matter ischemic change (WMIC) has been shown to be associated with acute brain infarction in the general population. WMIC has also been shown to be an independent predictor of non-focal neurocognitive changes, generalized seizures, and temporary neurologic dysfunction in ...
Blood-brain barrier: ageing and microvascular disease--systematic review and meta-analysis. Cerebral "microvascular" disease occurs in lacunar stroke, leukoaraiosis, vascular dementia and Alzheimer's disease. It may arise from or contribute to ins... AJ Farrall,JM Wardlaw - 《Journal of the Neu...
Conclusions We demonstrated that EPC-CM protected the brain from chronic ischemic injury and promoted functional recovery through MIF-mediated AKT pathway. These findings suggest EPC-CM holds potential as a novel cell-free therapeutic approach for treating CCI through the actions of MIF.Introduction...
2a). After exposure to CoCl2 or OGD, the proliferation of brain microvascular endothelial cells (BMECs) was increased with enhanced apoptosis by the quantification of EdU-positive and TUNEL-positive cells (Fig. 2b, c). ZO-1 and Claudin-5 in the immunostaining were both fractured at the ...
Indeed, AD patients show significantly worse cognition when they present chronic microvascular ischemic lesions, such as white matter hyperintensities7,8. One may hypothesize these changes derive from comorbid white matter dysfunction, which may affect brain function by interfering with inter-regional ...
levels of proinflammatory cytokines IL-1β, tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) in mice [15]. In a series of investigations, our laboratory revealed the effects of EtOH exposure on brain microvascular endothelial cells (BMVECs) and demonstrated a compelling link bet...
These widespread systemic effects exponentially increase the risk of cerebral microvascular damage, cerebral vascular toxicity, and cardio- and cerebral-vascular events (ischemic and hemorrhagic), with a consequent increase in the risk of lesions affecting the central nervous system [146]. Cocaine exerts...
The intrahepatic microvascular unit is made up of several discrete units, including portal venules, hepatic arterioles, sinusoids, central venules, and lymphatics. The cellular elements in these structures include endothelial cells, smooth muscle cells, and in the sinusoid, pericyte-like hepatic stella...
Predicting the course of kidney disease in individuals with both type 1 and type 2 diabetes mellitus (DM) is a significant clinical and policy challenge. In several regions, DM is now the leading cause of end-stage renal disease. The aim of this study to