Chronic microvascular white matter ischemic change (WMIC) has been shown to be associated with acute brain infarction in the general population. WMIC has also been shown to be an independent predictor of non-focal neurocognitive changes, generalized seizures, and temporary neurologic dysfunction in ...
Conclusions We demonstrated that EPC-CM protected the brain from chronic ischemic injury and promoted functional recovery through MIF-mediated AKT pathway. These findings suggest EPC-CM holds potential as a novel cell-free therapeutic approach for treating CCI through the actions of MIF.Introduction...
In reactive astrogliosis resulting from brain insults or neurodegenerative conditions, astrocytes respond by secreting extracellular effector molecules in a finely graduated continuum of progressive alterations in gene expression and cellular changes, which may be triggered or regulated by various intercellular ...
2a). After exposure to CoCl2 or OGD, the proliferation of brain microvascular endothelial cells (BMECs) was increased with enhanced apoptosis by the quantification of EdU-positive and TUNEL-positive cells (Fig. 2b, c). ZO-1 and Claudin-5 in the immunostaining were both fractured at the ...
Objective To analyze the correlation between the changes of learning and memory and the progressive degeneration of white matter nerve fibers and pericytes in the corpus callosum and hippocampus of rats with chronic cerebral ischemia, then to explore the mechanism of learning and memory impairment cause...
Indeed, AD patients show significantly worse cognition when they present chronic microvascular ischemic lesions, such as white matter hyperintensities7,8. One may hypothesize these changes derive from comorbid white matter dysfunction, which may affect brain function by interfering with inter-regional ...
levels of proinflammatory cytokines IL-1β, tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) in mice [15]. In a series of investigations, our laboratory revealed the effects of EtOH exposure on brain microvascular endothelial cells (BMVECs) and demonstrated a compelling link bet...
The increased diffusion values were observed despite negative or nonspecific results on routine MR imaging, indicating that this imaging modality may show early pathologic changes in the cellular and microvascular structure of the brain in boxers. Zhang et al.[114] postulated that given the similar ...
Compared to individuals without DM, those with the condition have a nearly twofold increased risk of developing CKD10, with 40% of those with type 2 DM experiencing diabetic nephropathy, a severe microvascular complication11. The decline in estimated glomerular filtration rate (eGFR) and the onset...
Effects of ginkgo biloba extract EGb761 on expression of RAGE and LRP-1 in cerebral microvascular endothelial cells under chronic hypoxia and hypoglycemia Alzheimer's disease (AD), characterized by accumulation of amyloid-beta protein (Aβ) in brain parenchyma, is closely associated with brain ische...