Chronic cerebral ischemia (CCI) is a significant health issue characterized by hypoperfusion due to damage or occlusion of the cerebral or carotid arteries. CCI may lead to progressive cognitive impairment that is considered as a prelude to neurodegenera
The transorbital approach is the best way to produce focal brain ischemia. Without any retraction of the brain tissue, the MCA can be occluded at its origin with a clip or ligature. A temporary occlusion can be produced by removal of the clip within six hours after its application to the ...
Oligovascular coupling contributes to white matter vascular homeostasis. However, little is known about the effects of oligovascular interaction on oligodendrocyte precursor cell (OPC) changes in chronic cerebral ischemia. Here, using a mouse of bilatera
<bold>Objective</bold> To analyze the correlation between the changes of learning and memory and the progressive degeneration of white matter nerve fibers and pericytes in the corpus callosum and hippocampus of rats with chronic cerebral ischemia, then t
(A1 astrocytes induced by inflammatory stimuli) promoting inflammation through upregulation of classical complement cascade genes, tissue damage and synaptic degeneration or a neuroprotective function (A2 astrocytes induced by ischemia) through trophic factors that promote either survival and growth of ...
Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia 来自 Semantic Scholar 喜欢 0 阅读量: 34 作者:AR Chade,X Zhu,OP Mushin,C Napoli,LO Lerman 摘要: We tested the hypothesis that statins would decrease renal injury in renal artery stenosis (RAS) by ...
Alzheimer's disease (AD), characterized by accumulation of amyloid-beta protein (Aβ) in brain parenchyma, is closely associated with brain ischemia. Decre... FL Yan,Z Ying,FD Zhao - 《Acta Neuropathologica》 被引量: 107发表: 2008年 Alzheimer's disease beta-secretase BACE1 is not a neur...
Introduction Structural and functional impairments of cerebral small vessels (CSVs) result in white matter hypo-perfusion and ischemia that are major cause of Cerebral small vessel disease (CSVD) or white matter disease is a variety of abnormalities in brain microvasculature. Recently, chronic kidney ...
Martin et al. proved that BTKi had promising therapeutic potential in myelin repair in ex vivo and in vivo lysophosphatidylcholine (LPC)-induced demyelination models [50]. However, the effect of BTKi on microglial function has not been investigated during chronic white matter ischemia. By utilizin...
G. et al. Neuronal RAGE expression modulates severity of injury following transient focal cerebral ischemia. J. Clin. Neurosci. 16, 302–306 (2009). Article CAS PubMed Google Scholar Muhammad, S. et al. The HMGB1 receptor RAGE mediates ischemic brain damage. J. Neurosci. 28, 12023–...