At least half of (predominant) female patients with recurrent angina, without signs of obstructive CAD, have underlying coronary microvascular dysfunction (CMD). Especially when signs of ischemia are present, this syndrome has an adverse prognosis. Patients with CMD have a characteristic symptom ...
the prognosis for patients with diabetes is worse than that for nondiabetic patients. Also, patients with diabetes tend to start dialysis earlier because they develop symptoms sooner than other patients with renal disease. Therefore, a renal transplant is the preferred method of treatment, if...
Despite prompt epicardial recanalization in patients presenting with ST-segment elevation myocardial infarction (STEMI), coronary microvascular obstruction and dysfunction (CMVO) is still fairly common and is associated with poor prognosis. Various pharmacological and mechanical strategies to treat CMVO have...
D. et al. Prognosis in women with myocardial ischemia in the absence of obstructive coronary artery disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE). Circulation 109, 2993–2999 (2004). Article ...
Coronary microvascular dysfunctionis a highly prevalent condition of both structural and functional coronary disorders in patients with angina and nonobstructivecoronary artery disease(ANOCA). Current diagnostic modalities to assess microvascular function are related to prognosis, but these modalities have seve...
Blood levels of microRNAs associated with ischemic heart disease differ between Austrians and Japanese: a pilot study Article Open access 12 August 2020 FKBPL is associated with metabolic parameters and is a novel determinant of cardiovascular disease Article Open access 10 December 2020 MicroRNA...
Microvascular coronary dysfunction and ischemic heart disease: where are we in 2014? Many patients with angina and signs of myocardial ischemia on stress testing have no significant obstructive epicardial coronary disease. There are many potential coronary and non-coronary mechanisms for ischemia without ...
Johnson BD et al (2004) Prognosis in women with myocardial ischemia in the absence of obstructive coronary disease: results from the National Institutes of Health-National Heart, Lung, and Blood Institute-Sponsored Women’s Ischemia Syndrome Evaluation (WISE). Circulation 109(24):2993–2999 Article...
hemorrhage; the temporal evolution of MO and its relationship to infarct healing, adverse LV remodeling and clinical prognosis; clinical trial applications; and future directions. Pathophysiology of microvascular dysfunction The contribution of microvascular injury in causing anatomic myocardial “no-reflow”...
Notably, when both functional (high IMR) and anatomic (MVO on CMR) impairment is evident, the long-term prognosis is significantly worse. Conversely, a margin of improvement and recovery can be expected when MVO is associated with some preservation of microvascular function, defined by IMR ≤40...