朱学娥,向芳,罗东,等. microRNA-27b、microRNA-221、microRNA-222和血管内皮生长因子在瘢痕疙瘩中的表达及相关性研究[J]. 中华整形外科杂志,2023,39(08):844-850.DOI:10.3760/cma.j.cn114453-20220808-00246 【摘要】 目的探讨瘢...
2020年9月,姚玮艳副主任医师在《CANCER CELL INTERNATIONAL》杂志发表题名为"MicroRNA-221-3p is related to survival and promotes tumour progression in pancreatic cancer: a comprehensive study on functions and clinicopathological value"...
目的 探讨不同剂量X线照射对人结直肠癌Caco2细胞系中microRNA-221 (miR-221)和张力蛋白在10号染色体上同源缺失的磷酸酶(PTEN)表达的影响。方法 常规培养Caco2细胞系并分为5组,分别给予不同剂量(0、2、4、6及8 Gy) 的X射线照射,24 h后提取细胞总RNA和蛋白质,应用real-time RT-PCR方法检测Caco2细胞中miR-...
神经胶质瘤患者脑脊液microRNA-221水平的测定及意义
背景:microRNA与椎间盘退变密切相关,腰突颗粒能显著延缓椎间盘退变进展。 目的:通过研究miR-221对髓核细胞增殖与凋亡功能的影响及腰突颗粒对miR-221的调控作用探讨腰突颗粒延缓椎间盘退变的机制。 方法:应用miR-221模拟物(模拟物组)及抑制剂(抑制剂组)转染大鼠髓核细胞,肿瘤坏死因子α诱导髓核细胞退变模型(模型组...
结论难治性癫痫合并CD患者血清miR-221-3p、NRGl水平较高，且miR-221-3p、NRGl均与难治性癫痫患者CD进程密切相关。关键词：难治性癫痫；神经调节蛋白1;microRNA-221-3p;认知功能；相关性 中图分类号：R742.1；R749.05文献标志码：A文章编号:1672-2353(2021)22-050-05D0I：10.7619/jcmp.20212229 Relations...
In this issue of EBioMedicine Yanan Cao and coworkers describe an intriguing cross-talk between microRNA 221/222 and TIMP3 [2], an inhibitor of metalloproteinase previously involved in hepatic inflammation and steatosis [3,4]. Using genetically modified mouse models the authors were able to knockd...
We have shown earlier that microRNA (miR)-221 and -222 are upregulated in tamoxifen (TAM) resistant breast cancer cell line MCF-7 (OHT), and in Her2 positive primary human breast tumors compared to the Her2 negative tumors. In addition, expression of miR-181b was 3.5-fold higher in OHT...
microRNA-19对肝癌细胞系迁移与侵袭能力的影响 mir-19的靶基因发现,许多癌基因3'UTR包含与mir-19的互补序列.结论 mir-19可能部分通过调节CREB3L4,PDE4A,JAM2,RUNX2等的表达来抑制肝癌细胞的增殖和侵袭转移... 朱俊杰%匡玉庭 - 《中国血液流变学杂志》 被引量: 0发表: 2010年 AF119895通过miR-6508-3p上调...