本研究旨在探究MicroRNA-22在癌症治疗中的功能及作用机制,为癌症治疗提供新的理论和实践基础。 研究方法: 1.搜集相关文献并对现有研究进行综合分析; 2.构建MicroRNA-22的过表达和沉默模型,通过细胞增殖、细胞凋亡、细胞周期、细胞分化和细胞移动等细胞生物学指标评估其在癌症治疗中的影响; 3.利用Western blotting、Rea...
MicroRNA-22 的功能研究的综述报告 在细胞生物学中,MicroRNA-22(miR-22)是一种广泛表达的非编码小RNA 分子,其 长度约为22 个核苷酸。该分子已被证明在多种生物学过程中发挥重要的调控作用,包 括细胞周期调节、细胞凋亡、血液系统发育、心脏发育和肌肉萎缩等领域。本文将总 结近年来有关miR-22 的功能研究。 mi...
microRNA-22 (miR-22) is an evolutionally conserved miRNA that is highly expressed in the heart. Recent studies uncovered miR-22 as an important regulator for cardiac remodeling. miR-22 modulates the expression and function of genes involved in hypertrophic response, sarcomere reorganization, and ...
然而,纤维化和肥大也导致了心脏重构,使心脏功能失代偿,最终发展为心力衰竭.近年来研究显示,microRNA (miRNA)在心血管疾病中具有重要的作用.microRNA-22 (miR-22)作为一种在心脏中高表达的miRNA,许多研究已证实miR-22在心肌梗死及心脏重构的过程中发挥了重要作用.本文主要总结了近年来的主要研究进展,包括miR-22对...
可能調控ErbB3的microRNA,結果發現 microRNA-22(mir-22)最具有潛力.我們利用ErbB3 RNAi(shRNA)抑制了MCF-7乳癌細胞的ErbB3蛋白表現,結果顯示ErbB3是癌細胞生長所必需的.當我們加miRNA-22到乳癌細胞時,miRNA-22會抑制ErbB3在乳癌細胞中的表現;另一方面,我們加miRNA-22抑製劑到肺癌細胞,miRNA-22抑製劑會增加...
被引量: 22发表: 2017年 Long noncoding RNA MEG3 inhibits proliferation of chronic myeloid leukemia cells by sponging microRNA21 Introduction: Extensive studies on SHP-1 protein and SHP-1 mRNA revealed that the diminishment or abolishment of the expression of SHP-1 in leukemias/lymph... Z Li,...
Accumulating evidence demonstrates that microRNA-22 (miR-22) was deregulated in many types of cancers and was involved in various cellular processes related to carcinogenesis. However, the exact roles and mechanisms of miR-22 remain unknown in human renal cell carcinoma (RCC). Here, the relationsh...
leads to heart failure. Extensive studies have revealed that microRNAs (miRNAs) play an essential role in cardiovascular diseases. microRNA-22 (miR-22) is one of the most abundant miRNA in the heart. Many studies have demonstrated that miR-22 plays critical roles in MI and subsequent cardiac ...
MicroRNA-22 Downregulation by Atorvastatin in a Mouse Model of Cardiac Hypertrophy: a new Mechanism for Antihypertrophic Intervention Subject Area: Further Areas Yingfeng Tu; Lin Wan; Lihong Bu; Dongliang Zhao; Dandan Dong; Tao Huang; Zhen Cheng; Baozhong Shen Cellular Physiology and ...