2021年12月27日,Clinical and Translational Discovery 杂志在线发表了天津南开大学Yiyao Jiang 教授团队的最新成果 “ MicroRNA-144-3p controls the apoptosis of pulmonary artery endothelial cells in pulmonary arterial hypertension v...
转录因子GATA-I和EKLF可以结合在microRNA-144 ～ 451基因簇并激活microRNA-144或microRNA-451的表达;在K562细胞中过表达microRNA-144或microRNA-451均可促进hemin诱导的红系分化;另一方面,microRNA-144和microRNA-451可以通过抑制GATA-2的表达促进细胞向红系分化.结论 microRNA-144～ 451基因簇在红系分化过程中...
OPEN Citation: Cell Death and Disease (2017) 8, e2597; doi:10.1038/cddis.2017.24 Official journal of the Cell Death Differentiation Association www.nature.com/cddis MicroRNA-144 is regulated by CP2 and decreases COX-2 expression and PGE2 production in mouse ovarian granulosa cells Jiawei Zhou1...
microRNA在间充质干细胞成骨分化中的调节作用 间充质干细胞分化为成骨细胞的过程中受到基因表达的精确调控.近年来诸多研究表明microRNA(miRNA)在间充质干细胞的成骨分化过程中发挥着重要的调节作用.miRNA是一类小... 王俊成,刘洪臣 被引量: 0发表: 2012年 miR-125b在C3H10T1/2间充质干细胞成骨分化过程中的...
微小RNA(micro RNA,miRNA)是一类新兴的代谢非肽调节因子,主要作用于转录后水平.已知miRNA在多种基本生物学过程中起关键作用.现已证明细胞培养中被脂质过载抑制或诱导的miRNA已被证明通过与特定RNA靶标的相互作用来调节脂质诱导的细胞死亡进程.但是,迄今为止,miRNA介导的对心肌脂毒性的相关机制尚不明确.因此本研究旨在...
The current work was designed to investigate the potential roles of microRNA-144 (miR-144) in the diagnosis and prognosis of RB. Methods: miR-144 expression levels in RB tissues and adjacent normal tissues, as well as serum samples from RB patients and healthy controls were measured. The ...
Analysis of a microRNA (miRNA) expression signature of bladder cancer (BC) by deep-sequencing revealed that clustered miRNAs microRNA (miR)-451a, miR-144-3p, and miR-144-5p were significantly downregulated in BC tissues. We hypothesised that these miRNAs function as tumour suppressors in BC....
大鼠卵巢中microRNA-144表达,发现模型组中该表达显著下降,中药治疗后显著升高.WB测定AKT/mTOR,自噬相关蛋白,结果发现以上指标在模型组中的表达分别受到抑制和促进作用,中药治疗后,均有改善.结论补肾宁心汤对POI大鼠的卵巢功能有保护作用,可改善大鼠内分泌和减缓卵泡闭锁,起效的机制可能与上调microRNA144/AKT/mTOR通路...
The development of effective drug delivery systems capable of transporting small interfering RNA (siRNA) has been elusive. We have previously reported that colorectal cancer tumor xenograft growth was arrested following treatment with liposomal preparati
Conclusion miRNA-144 is highly expressed in MDS, and may be a new biomarker for prognosis evaluation of MDS.%目的:探讨miRNA-144在骨髓增生异常综合征(MDS)患者外周血中的表达情况及其临床意义。方法收集MDS患者24例,健康对照12例,qRT-PCR检测外周血miRNA-144相对表达量,统计分析miRNA-144在MDS中...