derived cell types revealed that the miR-141 messenger RNA levels overall inversely correlated with the abundance of CD44+cells (Fig. 1b). Importantly, the miR-141 levels were much lower in the CD44+cells freshly purified from 21 primary human PCa (HPCa) patient samples (Supplementary Table 2...
目前关于氧化应激的调控研究中,Keap1/Nrf2信号通路是一条重要的调控通路.非编码RNA是内源性单链小RNA分子,可以通过匹配多个靶标而产生相同的生物学效应.本次研究重点探讨在体外模拟糖尿病高氧化应激状态下,miR-141-3p能否通过Keap1/Nrf2信号通路达到调控角质细胞的氧化应激的效果,并深入地探讨了其相关的分子机制,为...
MicroRNA-141 (miR-141) has been reported to function as tumor suppressor in many types of cancer. However, the molecular function and underlying mechanisms of miR-141 in glioma is still unknown. The aims of this study were to investigate miR-141 expression and determine its biological function...
有鉴于此,本发明的目的在于提供一种MicroRNA-141作为抑制剂的用途,具体地,提供MicroRNA-141作为抑制剂通过抑制TAZ基因的表达,达到抑制胃癌转移的目的。 本发明采取的技术方案如下: 1、TAZ表达抑制剂在制备治疗TAZ过度表达引起的癌症药物中的应用,所述TAZ表达抑制剂含有如SEQIDNo.1所示序列。 优选的,所述TAZ表达抑制...
图5.(A) 传感器的Pmax曲线: a-c: logCmi21=logCmi141=−14.00,−12.00, −10.00. (B) △Pmax与目标物microRNA-21(实线)和microRNA-141(虚线)浓度的关系曲线。扫速ν=1 mV s-1.(C) 干扰测试:空白血清,5.00×10-12 M has-miR-125a-3p,5.00×10-12M 单碱基错配miRNA,1.00×10-14 M miR...
青岛大学 硕士学位论文 MicroRNA--21和--141在上皮性卵巢癌患者组织和血清中的表在 及临床意义的探讨 姓名:***申请学位级别:硕士 专业:妇产科学 指导教师:**真 20110529 摘要 目的:探讨微小RNA-21和.141(miR-21和miR-141)在卵巢癌患者组织和血清中的 表达情况并初步探讨其作为肿瘤标记物早期诊断上皮性卵巢...
(6)完成步骤(5)microrna-141的电信号检测后,在纸芯片b光电信号采集区和光热温度采集区继续加入30µl浓度为10mm的盐酸,室温下反应30min,再加入10µl浓度为90mm的亚铁氰化钾,室温下反应30min,形成具有光热效应的普鲁士蓝纳米粒子,并通过808nm功率为4.5w的近红外光下照射200s后,用电子温度计测定温度变化,绘制温...
MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24 Yu KR,Lee S,Jung JW,et al.MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24.Journal of Cell Science. 2013MicroRNA-141-3p plays a role in hum...
GSE71533数据集分析结果也显示miR-141在胰腺癌组织中下调;Western blot分析结果表明Bmi-1在胰腺癌细胞中高表达,双荧光素酶实验表明miR-141锚定在Bmi-1的3'非编码区,下调Bmi-1可以抑制胰腺癌细胞的增殖;上调miR-141可以降低Bmi-1的蛋白质表达水平,从而抑制胰腺癌细胞中细胞增殖.结论:miR-141通过靶向Bmi-1在胰腺...
. MicroRNA-145 is regulated by DNA methylation and p53 gene mutation in prostate cancer. . A Contemporary Prostate Cancer Grading System: A Validated Alternative to the Gleason Score. Journal of clinical oncology: official journal of the American Society of Clinical Oncology ...