MicroRNA-140 或可催生关节炎治疗新方法 日本研究人员日前发现了一种对防止关节炎具有重要作用的小分子,有可能催生治疗关节炎和类风湿性关节炎的新方法。 日本国立儿童健康和发展研究所系统发生和再生医学研究部主任浅原弘嗣等研究人员注意到,人类和实验鼠的软骨细胞中富含“miR140”分子,这是一种微型核糖核酸,也即...
MicroRNA-140
关键词: microRNA-140 组蛋白去乙酰化酶 大鼠骨髓间充质干细胞 成软骨诱导 摘要: 目的 检测组蛋白去乙酰化酶7(HDAC7)是否为MicroRNA(miRNA)-140的靶基因,并研究在大鼠骨髓间充质干细胞(ratMSCs)成软骨诱导分化中miRNA-140和HDAC7表达的相关性.方法 利用生物信息学、双荧光素酶报告基因检测以及Western blot法鉴...
MicroRNA-140或可催生关节炎治疗新方法
In this study, the expression of microRNA-140 (miR-140) was demonstrated to be significantly suppressed in pancreatic duct adenocarcinoma specimens and cell lines, compared with their adjacent normal tissues. With the help of bioinformatics analysis, inhibitor of apoptosis-stimulating protein of p53 ...
Here we describe a neomorphic seed region mutation in the chondrocyte-specific, super-enhancer-associated MIR140 gene encoding microRNA-140 (miR-140) in a novel autosomal dominant human skeletal dysplasia. Mice with the corresponding single nucleotide substitution show skeletal abnormalities similar to ...
microRNA-140 upregulated many of the components involved in the synthesis of hyaline extracellular matrix and reduced the levels of aggrecanases and syndecan 4, thus potentially both increasing cartilage repair and reducing cartilage breakdown. These results show how forced expression of microRNA-140 ...
微小RNA-140 关节软骨 骨关节炎 摘要: 骨关节炎( OA)是一种以细胞外基质( ECM)渐进性破坏,滑膜、软骨、软骨下骨及关节内其他组织的改变为特点的高发疾病。微小RNA( microRNA或miRNA)属于非编码区小RNA,其通过调控基因的表达对组织生长和稳态进行控制。在已知的miRNA中,MicroRNA?140(miR?140)特异性高表达于...
In this study, we identified microRNA-140 (miR-140) as a direct downstream component of the BMP4 signaling pathway during the commitment of C3H10T1/2 cells to adipocyte lineage. Overexpression of miR-140 in C3H10T1/2 cells promoted commitment, whereas knockdown of its expression led to ...
MicroRNA-140-5p suppresses tumor growth and metastasis by targeting transforming growth factor β receptor 1 and fibroblast growth factor 9 in hepatocellul... Yang H,Fang F,Chang R,Yang L.Microrna-140-5p suppresses tumorgrowth and metastasis by targeting transforming growth factor betareceptor1and...