已有研究证明microRNA(miRNAs)在肌肉细胞增殖和分化过程中发挥了重要作用,目前有关miRNAs对牛肌肉生长发育影响的相关研究还比较少,本研究通过建立牛骨骼肌卫星细胞体外成肌诱导分化模型,结合前期研究结果,对miR-128在牛骨骼肌卫星细胞增殖及成肌分化过程中所起到的调控作用进行了深入研究.1.本研究采用胶原酶联合胰酶的酶...
microRNA_128_肿瘤治疗新靶点_曹建刚
microRNA128:肿瘤治疗新靶点 下载积分: 5000 内容提示: ·综述与讲座·microRNA⁃128: 肿瘤治疗新靶点∗∗ 基金项目:国家自然科学基金资助项目 (81270420);湖南省高校创新平台开放基金资助项目(10K051);湖南省自然科学基金省市联合(衡阳)基金重点项目(12JJ8013)1 通讯作者,E⁃mail:lxchen6@126.com421001 ...
The goal of replenishing the cardiomyocyte (CM) population using regenerative therapies following myocardial infarction (MI) is hampered by the limited regeneration capacity of adult CMs, partially due to their withdrawal from the cell cycle. Here, we show that microRNA-128 (miR-128) is upregulat...
Taken together, our study demonstrates that miR-128 can inhibit proliferation of glioma cells through one of its targets, E2F3a. This is a preview of subscription content, log in via an institution to check access. Similar content being viewed by others MicroRNA-29a inhibits glioblastoma stem ...
Keywords: chemoresistance; E2F5; microRNA-128-2; mutant p53; NSCLC; p21waf1 Abbreviations: NCSL, non-small-cell lung cancer; wt, wild-type; miRNA, microRNA; TSS, transcription start site; ChIP, chromatin immunoprecipitation; CDDP, cisplatinum; DOXO, doxorubicin; 5-FU, 5-fluorouracil; Pon-A...
Proteomic screening and identification of microRNA‐128 targets in glioma cells 来自 国家科技图书文献中心 喜欢 0 阅读量: 116 摘要: Brain-enriched miR-128 is repressed in glioma cells, and could inhibit the proliferation of gliomas by targeting genes such as E2F3a and BMI1. To identify more ...
Next, miR-128-3p levels were determined by RT-qPCR of RNA from synaptoneurosome fractions isolated from the hippocampi and forebrains of RML scrapie prion infected mice and mock infected controls at an early and late stage of disease. As a number of miR-128-3p targets were glutamate ...
Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal. Otsuki, G. Nuovo, et al., Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal, ... J Godlewski,MO ...