Gut-innervating nociceptors regulate the intestinal microbiota to promote tissue protection. Cell 185, 4170–4189.e4120 (2022). Article CAS PubMed PubMed Central Google Scholar Yang, D. et al. Nociceptor neurons direct goblet cells via a CGRP–RAMP1 axis to drive mucus production and gut ...
120]. In germ-free mice, exposure to a restraint stress triggers an exaggerated HPA axis response, as compared to specific pathogen-free control mice. Such an aberrant response is normalized through intestinal colonization byBifidobacterium longumsubsp. infantis, and...
Recently, many researchers have paid close attention to the development of intestinal microbiota with a belief that this previously “neglected organ” has a fundamental role in many disorders, such as diabetes [3], Alzheimer's disease [4], obesity [5], and kidney disease [6]. Further, ...
Forslund等的研究发现,二甲双胍处理后个体的肠道埃希氏菌数量显著增加,丁酸和丙酸产生潜力显著增强,这些短链脂肪酸在结肠产生后通过互补机制触发了肠道糖异生(intestinal gluconeogenesis, IGN),IGN的增加对葡萄糖和能量稳态有益,减少了肝脏糖异生,这表明了二甲双胍的药效在一定程度上是由微生物介导的[65]。Sun等通过...
Postnatal development of the gastrointestinal tract involves the establishment of the commensal microbiota, the acquisition of immune tolerance via a balanced immune cell composition, and maturation of the intestinal epithelium. While studies have uncove
intestinal hormones such as glucagon-like peptide 1 (GLP-1), which transfer indirect signals to the brain through vagus nerve and systemic pathways. All of these pathways ultimately affect learning, mood, and memory (Dalile et al.2019). Alzheimer’s disease (AD) is a major reason for ...
Our studies support the hypothesis that intestinal microbiota may help protect against AD, in part, by supporting the generation of select SCFAs, which interfere with the formation of toxic soluble Aβ aggregates. 展开 关键词: Alzheimer’ s disease, beta-amyloid (Aβ ), fibrils,...
Chronic Gut Virus May Play a Role in Alzheimer’s Development Researchers have linked chronic intestinal infections caused by cytomegalovirus (HCMV) to a unique subtype of Alzheimer’s disease. The virus may travel from the gut to the brain via the vagus nerve, altering immune responses and cont...
. SCFAs and other metabolites produced by intestinal flora may directly or indirectly impact brain function [12]. Neuroinflammation and changes in blood-brain-barrier (BBB) permeability may result in deregulation of these pathways [13]. APP/PS1 mice carry two transgenes associated with Alzheimer’s...
Alzheimer’s disease (AD) is the most common dementia in the elderly. Treatment for AD is still a difficult task in clinic. AD is associated with abnormal gut microbiota. However, little is known about the role of fecal microbiota transplantation (FMT) in AD. Here, we evaluated the efficacy...