In conclusion, a temporary disruption of the gut microbiota in early-life results in very specific and long-lasting changes in visceral sensitivity in male rats, a hallmark of stress-related functional disorders of the brain-gut axis such as irritable bowel disorder....
Colonization of pathogen bacteria in the gut and their metabolites (endotoxins) leads to immune response. Microorganisms affect the brain via the immune system, neuroendocrine system, and nervus vagus. Nutrition, stress, and medication lead to dysbiosis by changing the microbiota composition. It is ...
Consideration of the role of the brain–gut–kidney axis in the maintenance of normal homeostasis and of dysregulation of this axis in CKD and hypertension could lead to the identification of novel therapeutic targets. In addition, the discovery of unique microbial communities and their associated ...
gut microbiota–brain axisinflammasomekynurenine pathwaymajor depressive disorderneuroinflammationMajor depressive disorder (MDD) is a psychiatric condition that affects a large number of people in the world and the treatment existents do not work for all individuals affected. Thus, it is believed that ...
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal hosts to regulate the development and function of the immune, metabolic and nervous systems through dynamic bidirectional communication along the ‘gut–brain axis’. These processes may affect human health, as...
We will focus on the influence of stress on the microbiota and the mechanisms by which microbiota can affect the stress response and behavioral outcomes with an emphasis on visceral pain. 展开 关键词: Brain‐Gut axis Gut microbiota Stress Visceral Pain ...
As the gut microbiome provides essential cues to microglia, astrocytes, and oligodendrocytes, we examine the communications between gut microbiota and these glial cells during healthy states and neurodegenerative diseases. Subsequently, we discuss the mechanisms of the microbiota–gut–brain axis in ...
The gut microbiota is vital to human health10,11. Notably, the brain-gut axis has been intensively studied in the past few years12,13,14. Prior studies have reported that the gut microbiota exhibits circadian rhythms, which interact with host circadian rhythms15,16,17. Sleep disturbances, such...
With the recognition of the importance of the gut–brain axis in Parkinson’s disease (PD) etiology, there is increased interest in developing therapeutic strategies that target α-synuclein, the hallmark abhorrent protein of PD pathogenesis, which may originate in the gut. Research has demonstrated...
Bidirectional gut-brain axis interactions and the common factors contributing to the gut–brain activity Full size image Many pathways have been proposed to mediate the communication within the gut-brain-axis. The signal passage along gut-brain-axis involves the interactions among autonomic nervous syst...