RORγt+ MHCII+ type 3 innate lymphoid cells (ILC3) have also been implicated in the instruction of microbiota-specific Tregs. While RORγt+ APCs have been actively investigated in mice, the identity and function of these cell subsets in humans remain elusive. Herein, we identify a rare ...
MHCII Is Expressed, but Also Acquired, by ILC2s We confirmed MHCII expression on ∼50%–70% of naive wild-type (WT) ILC2s (Lin–Klrg1+CD25+ST2+ICOS+Sca1hiGATA3+IL-13+) and those elicited in response to IL-25 or IL-33, as compared to ILC2s from MHCII-deficient mice (H2-Ab1...