MHC class Ib-restricted CD8+ T cellsTbetThe importance of classical CD8+ T cells in tumor eradication is well acknowledged. However, the anti-tumor activity of MHC (major histocompatibility complex) Ib-restricted CD8+ T (Ib-CD8+ T) cells remains obscure. Here, we show that CX3CR1-...
Our understanding of the classical MHC class I molecules (MHC class Ia molecules) has long focused on their extreme polymorphism. These molecules present peptides to T cells and are central to discrimination between self and non-self. By contrast, the fu
By contrast, the functions of the non-polymorphic MHC class I molecules (MHC class Ib molecules) have been elusive, but emerging evidence reveals that, in addition to antigen presentation, MHC class Ib molecules are involved in immunoregulation. As we discuss here, the subset of MHC class Ib ...
MHC class Ib Antibody (130) References: Polymorphism and evolution of HLA class I and II genes and molecules.| Little, AM. and Parham, P. 1999. Rev Immunogenet. 1: 105-23. PMID: 11256568 Accessory proteins that control the assembly of MHC molecules with peptides.| Van Kaer, L. 2001....
Infection of B6 mice with the intracellular pathogen Listeria monocytogenes (LM) results in the activation of CD8(+) T cells that respond to Ag presented by both MHC class Ia and class Ib molecules. Enzyme-linked immunospot analysis reveals that these CTL populations expand and contract at differ...
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A limited number of MHC class I-b molecules have been shown to present pcptidcs to T cells. Among these molecules is the T23 encoded protein, Qa-l>, which is recognized by αβ and γδ T cells. Qa-1b is widely expressed in mouse tissues and its predicted peptide binding groove is...
This population can be detected 3 days following infection, represents up to 15% of the TCRgammadelta(+) iIELs, and is dependent on the MHC class Ib molecule T23 (Qa-1). Qa-1 is expressed by intestinal epithelial cells and thus accessible for iIEL recognition. Such cells may play a ...
The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes— M4, M5 , and M6 —which are orthologous between the two species. M4 and M6 are pseudogenes in the ...