The present invention relates to a novel tumor-associated antigens, it is as independent of the presentation via the MHC, induces a CD8 + T cell response. GM-CSF receptor -chain (CSF2RA) and tyrosinase-related protein 2 (TRP-2) is, on the surface of HLA I-negative melanoma cells, it...
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2B4 is a prototypical MHC-independent inhibitory receptor. It inhibits NK-cell responses to CD48-expressing cells in mice, as well as in the absence of SAP (signalling lymphocytic activation molecule (SLAM)-associated protein) in humans. This inhibition protects against NK-cell autoreactivity. ...
MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-induced transfer colitis. Eur.J.Immunol. 2004;34:705-714.Krajina T, Leithauser F, Reimann J. MHC class II-independent CD25+ CD4+ CD8alpha beta+ alpha beta T cells attenuate CD4+ T cell-...
Moreover, we provide evidence that DN T cells can differentiate in MHC-deficient mice. Our study demonstrates that MHC-independent thymic selection can yield DN T cells that are distinct from NKT, γδ T, mucosal-associated invariant T, and CD8αα T cells. 展开 ...
MHC-Independent Genetic Factors Control the Magnitude of CD4+ T Cell Responses to Amyloid-β Peptide in Mice through Regulatory T Cell-Mediated Inhibition. Toly-Ndour C, Lui G, Nunes MM, Bruley-Rosset M, Aucouturier P, Dorothee G (2011) MHC-independent genetic factors control the magnitude of...
VM CD8 T cells contribute to a superior therapeutic effect on MHC class I-deficient tumors. Using humanized mouse models or primary human CD8 T cells, we also demonstrated that chemotherapy-treated human lymphomas activated VM CD8 T cells independent of tumor-derived MHC class I. In conclusion,...
MHC independent anti-tumor immune responses induced by HSP70-enriched exosomes generate tumor regression in murine models. Cancer Lett. 2009, 275, 256-265. [CrossRef] [PubMed]Cho, J., Lee, Y.-S., Kim, S.-H., Ko, J.-K., Kim, C.-W., 2009. MHC independent anti-tumor im- mune...
Recent evidence has established that non-MHC-encoded molecules of the CD1 family mediate MHC-independent pathways for antigen presentation and T cell activ... M Sugita,MB Brenner - 《Seminars in Immunology》 被引量: 61发表: 2000年 Transcriptional profiling of innate and adaptive human immune respo...
British Journal of Cancer (2012) 106, 1123 – 1133 & 2012 Cancer Research UK All rights reserved 0007 – 0920/12 www.bjcancer.com The ganglioside antigen GD2 is surface-expressed in Ewing sarcoma and allows for MHC-independent immune targeting S Kailayangiri1, B Altvater1, J Meltzer1, S ...