接下来，作者验证了MHCIIhi中性粒细胞是否在体内表现出促瘤功能。为此，作者从慢性感染了PAO1的乳腺癌小鼠的肺中分离出的MHCIIhi和MHCIIlow中性粒细胞，在4T1细胞接种小鼠后的第11、14、17天将中性粒细胞输送到肺中，第21天处死小鼠，发现与其他组相比，MHCIIhi组的转移性肺结节数量显著增加。图4. MHCIIhi中性...
Conclusions: PA medial fibrosis is a causative factor of PH, and the inhibition of MHCIIhiLYVE1loCCR2hi iMΦ pathogenicity or infiltration reverses PA medial fibrosis and thus alleviates PH.doi:10.1161/circ.150.suppl_1.4137240Fan Qiu, MD, PhD...
Using multimarker flow cytometry and RNA expression array analyses on macrophage subpopulations from wound granulation tissue, we identified a Ly6cloMHCIIhi“noninflammatory” subset that increased both in absolute number and proportion during normal wound healing and was missing in Ob/Ob and MYD88-/...
Clinically Relevant Allergen Mixture Induces Robust Immune Response By Increasing CD11c+CD11b+MHCIIhiCD103int Lung Dendritic CellsFemale Balb/c mice were sensitized intranasally and challenged by aerosolizing a combination of house dust mite, ragweed and or PBS for a total of 5 weeks. Lung tissu...
FACS analysis suggested that decreased Ly6c lo MHCII hi AMs might make the major contribution to attenuated fibrogenesis in RBP‐J cKO mice, probably by reduced inflammatory factor release and enhanced matrix metalloproteinases expression. Using clodronate‐mediated macrophage depletion in RBP‐J ckO ...
百度试题 结果1 题目辅助性CD4+T细胞识别的抗原Oo A. MHC-H类抗原 B. MHC-I类抗原 C. MHC-EII类抗原 D. H1.A-HI类抗原 相关知识点: 试题来源: 解析 [答案]A [解析]MHC-II类抗原能识别并提呈外源性抗原肽给CD4+T细胞。反馈 收藏
“Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils”的研究论文,该研究首次证实慢性肺部细菌感染能促进乳腺癌的肺转移进程,并鉴定到一群名为MHCIIhi的中性粒细胞亚群在促进乳腺癌转移的过程中发挥着重要作用,结果表明,MHCIIhi中性粒细胞...
“Chronic pulmonary bacterial infection facilitates breast cancer lung metastasis by recruiting tumor-promoting MHCIIhi neutrophils”的研究论文,该研究首次证实慢性肺部细菌感染能促进乳腺癌的肺转移进程,并鉴定到一群名为MHCIIhi的中性粒细胞亚群在促进乳腺癌转移的过程中发挥着重要作用,结果表明,MHCIIhi中性粒细胞...
MHC IIhi CD11c+ migratory DCs present C. albicans-derived antigen in the cervical lymph nodes.Kerstin, TrautweinWeidnerAndré, GladiatorFlorian, R. KirchnerSimone, BecattiniThomas, RülickeFederica, SallustoSalomé, LeibundGutLandmann
Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(low) mediates tumor progression in mice. BMC Immunol. 2011;12:43.Wang B, Li Q, Qin L, Zhao S, Wang J, Chen X (2011) Transition of tumor-associated macrophages from MHC class II(hi) to MHC class II(...