Camel leukocytes were separated by hypotonic lysis of erythrocytes and separated cells were labeled with monoclonal antibodies to CD14, CD172a and MHCII molecules and analyzed by flow cytometry. A) Mononuclear cells (PBMC, encircled region) were identified based on their forward (FSC) and side ...
High MHCII expression was observed on larger proportions of WAMs along the healing course, from 24.5% (±1.2%) on D1 to D40.2% (±3.5%) by D7 (P=0.0002; Figure 2b). When combined with Ly6c, four WAM populations with distinct dynamics could be discriminated: the Ly6cloMHCIIlo (L-M...
Mechanical allodynia is attenuated and linked with higher peripheral opioidergic tone in TASTPM model of Alzheimer's Disease.Higher number of macrophages and CD206+/MHCIImacrophage population accumulate at nerve injury site in TASTPM mice.Fewer Ly6Chigh monocytes circulate in TASTPM bloodstream.TASTPM...
Together, these data highlight that ILC2s and T cells enter an antigen-dependent crosstalk that results in their subsequent activation and potentiation of type-2 immune responses and requires the expression of both MHCII and the costimulatory molecules CD80 and CD86 on ILC2s. Crosstalk between ILC...
We observed that microglia do not express MHCII whereas myeloid infiltrates express high levels of MHCII and CD40 96 h after SE. This antigen-presenting... J Vinet,ID Vainchtein,C Spano,... - 《Glia》 被引量: 18发表: 2016年 Mechanisms of Cross-Presentation in Graft-Vs-Host Disease 68...
A. seem unable to control high rents B. are successful C. are favoured by builders and landlords D. will be cancelled 查看完整题目与答案 下列关于处方药与非处方药的错误表述为 A. 国家对药品实行处方药与非处方药的分类管理制度于2000年12月1日实行 B. 处方药与非处方药由医...
B cells expressing high affinity antigen receptors are advantaged in germinal centers (GC), perhaps by increased acquisition of antigen for presentation to follicular helper T cells and improved T-cell help. In this model for affinity-dependent selection
In addition, CD45intCD11bint MPCs had higher phagocytic function in the normal kidney (35.6%±3.3% vs. 24.1%±2.2%, P = 0.04), but lower phagocytic capacity in post-ischemic kidney (54.9%±1.0% vs. 67.8%±1.9%, P < 0.01) compared to the CD45highCD11b+ population. Moreover, the...
Accordingly, circulating TASTPM Ly6Chigh (classical) monocytes, which are pro-inflammatory and infiltrate at the site of injury, were less abundant than in WT. In in vitro experiments, TASTPM bone marrow-derived macrophages showed efficient phagocytosis of myelin extracts containing amyloid precursor ...
Together, these results highlight the synergistic dynamics of immune cell crosstalk in driving CHIKV immunopathogenesis. This study provides new insights in the disease mechanism and offers opportunities for development of novel anti-CHIKV therapeutics. 展开 ...