Sari G, Rock KL. Tumor immune evasion through loss of MHC class-I antigen presentation. Curr Opin Immunol. 2023 Apr 30;83:102329. St Paul M, Ohashi PS. The Roles of CD8+ T Cell Subsets in Antitumor Immunity. Trends Cell Biol. 2020 Sep;30(9):695-704. Zhou Y et al. Activation of...
The efficiency of TAP-independent presentation may be impacted by the availability of receptive MHC-I, and in turn by the functional presence in the ER of the peptide-loading complex, itself anchored on TAP. Without TAP, surface expression of human leukocyte antigen (HLA)-B allotypes varies ...
such as acute myeloid leukemia (AML), do not respond or develop resistance. A potential mode of resistance is immune evasion of T cell immunity involving aberrant major histocompatibility complex class I (MHC-I) antigen presentation (AP). To map such mechanisms of resistance, we identified key ...
ANTIGEN presenting cellsT cellsDISEASESantigen presentation: monotonous mhc sing in troubled timesifier (Qdm) from the signal sequence of classical MHC class I molecules, to inhibitory natural killedoi:10.1038/nri2719BordonYvonneNature Reviews Immunology...
5.Dhatchinamoorthy, K., Colbert, J.D., and Rock, K.L. (2021). Cancer Immune Evasion Through Loss of MHC Class I Antigen Presentation.Front Immunol12, 636568. 10.3389/fimmu.2021.636568. 6.Gettinger, S., Choi, ...
Description: This SF1-1.1.1 monoclonal antibody reacts with the H-2Kd MHC class I alloantigen. H-2Kd is involved in antigen presentation to T cells expressing CD3/TCR and CD8. Reactivity to other haplotypes (e.g. b, j, k, p, q, s, and v) has not been observ...
Subsequent epitope spreading depended on antigen presentation and was compartmentalized by major histocompatibility complex (MHC). B cells carrying two MHC haplotypes could bridge the MHC barrier between B cells that did not share MHC. Thus, B cells directly relay autoreactivity between two separate ...
Before their exposition on the cell surface, the MHC class II molecules react with endocytosed exogenous antigens, which are then presented to the T cells. The antigen-binding grove between MHC class II alpha and beta chain is open at both ends and is 15...
This paper describes the progress of antigen presentation mediated by major histocompatibility complexⅠ( MHC-Ⅰ) molecule,as well as the countermeasures and specific molecular mechanisms exploited by viruses to evade this type of immunity,which are helpful for understanding the mechanisms associated with...
Philip, MHC class I antigen presentation and implications for developing a new generation of therapeutic vaccines., Ther. Adv. Vaccines. 2 (2014) 77-89... JD Comber,R Philip - 《Therapeutic Advances in Vaccines》 被引量: 63发表: 2014年 DNA vaccination: Antigen presentation and the induction...