By utilising cell lines that are defective in DM genes, we are elucidating some of the characteristics and functions of DM genes in MHC class II antigen presentation. It appears that DM interaction with MHC class II molecules is species specific....
Various new findings from the area of cell biology have consequences for MHC class I and MHC class II antigen presentation. The immune system is a relatively late addition in our progress through evolution, and many immune-specific molecules exist. Unique functions of some of these, including ...
MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Proximal tubular (PT) epithelial cells express MHC class II (la) antigens in immunologically-mediated renal injury. To study the role of PT as accessory cells, we generated several murine PT-like ...
Subsequent epitope spreading depended on antigen presentation and was compartmentalized by major histocompatibility complex (MHC). B cells carrying two MHC haplotypes could bridge the MHC barrier between B cells that did not share MHC. Thus, B cells directly relay autoreactivity between two separate ...
2021年3月瑞士苏黎世大学实验免疫学研究所病毒免疫生物学教授Christian Münz于Nature communications发表文章Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation其研究发现N...
Description: This AF6-120.1 monoclonal antibody reacts with the mouse MHC Class II I-Ab alloantigen of H-2b bearing mouse strains, including C57Bl/6 and 129. This cell surface molecule is involved in antigen presentation to T cells expressing CD3/TCR and CD4. The AF6-120.1 an...
The success of immunotherapy against human cancers relies on somewhat ill-defined correlates. While a role for CD4+ T lymphocytes in the control of tumor growth is well established, we are still looking for ways to harness the MHC class II antigen presen
Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthes...
英文别名 D6S221E antibody | DMA antibody | DMB antibody | DP beta 1 antibody | DP beta 1 chain antibody | DP(W4) beta chain antibody | DPB 1 antibody | DPB1 antibody | DPB1_HUMAN antibody | DRB antibody | H2Ea antibody | HLA class II histocompatibility antigen ant 规格或纯度 已...
Presentation of peptide antigens by MHC-II proteins is prerequisite to effective CD4 T cell tolerance to self and to recognition of foreign antigens. Antig