Our current view of this important cellular process as it relates to antigen presentation to CD8 T cells is based on many different approaches: biochemical, genetic, structural, computational, cell biological, and immunological. In this review, taking advantage of recent X-ray...
在APC与T细胞接触的过程中, 表达于APC表面的抗原肽-MHC复合物被T细胞所识别,从而将抗原信息呈递给T细胞,此过程统称为抗原提呈(antigen presentation)。 根据来源不同可将提呈的抗原分为两大类(图11-1):来源于APC之外的抗原称为外源性抗原(exogenous antigen),如被吞噬的细胞、细菌、蛋白质抗原等;细胞(靶细胞或广义...
Sari G, Rock KL. Tumor immune evasion through loss of MHC class-I antigen presentation. Curr Opin Immunol. 2023 Apr 30;83:102329. St Paul M, Ohashi PS. The Roles of CD8+ T Cell Subsets in Antitumor Immunity. Trends Cell Biol. 2020 Sep;30(9):695-704. Zhou Y et al. Activation of...
4.Jhunjhunwala, S., Hammer, C., and Delamarre, L. (2021). Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion.Nat Rev Cancer21, 298-312. 10.1038/s41568-021-00339-z. 5.Dhatchinamo...
antigen presentationautophagyMHC class I molecules on the cellular surface display peptides that either derive from endogenous proteins (self or viral), or from endocytosis of molecules, dying cells or pathogens. The conventional antigen-processing pathway for MHC class I presentation depends on ...
摘要: SynonymsSynonymsmajor histocompatibility complex class I antigen presentationDefinitionDefinitionMHC class I antigen presentation is the process by which antigen-presenting cells express foreign antigDOI: 10.1007/3-540-27806-0_976 被引量: 207 ...
LC3 and NLRC5 interaction inhibits NLRC5-mediated MHC class I antigen presentation pathway in endometrial cancer The major histocompatibility complex class I (MHC-I) transactivator, nucleotide binding oligomerization domain-like receptor family caspase recruitment dom... L Zhan,J Zhang,X Liu,... - ...
This protein is an MHC class I alloantigen, which is involved in antigen presentation to T cells expressing CD3/TCR and CD8.HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-perfo...
4.Jhunjhunwala, S., Hammer, C., and Delamarre, L. (2021). Antigen presentation in cancer: insights into tumour immunogenicity and immune evasion. Nat Rev Cancer 21, 298-312. 10.1038/s41568-021-00339-z. 5.Dhatchi...
Targeting LSD1 rescues MHC class I antigen presentation and overcomes PD-L1 blockade resistance in small cell lung cancer (J Thorac Oncol;IF:15.609) Nguyen EM, Taniguchi H, Chan JM et al. Targeting LSD1 rescues MHC...