Protein degradation in MHC class II antigen presentation: opportunities for immunomodulation. Semin. Cell Dev. Biol. 11: 203-210.Medd, P. G., and B. M. Chain. 2000. Protein degradation in MHC class II antigen presentation: opportunities for immunomodulation. Cell. Dev. Biol. 11:203....
In this Review, we bring this into context with the current understanding of the general MHC class I antigen presentation process. The biology of MHC molecules touches almost all areas in the field of cell biology. Various new findings from the area of cell biology have consequences for MHC ...
MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells. Proximal tubular (PT) epithelial cells express MHC class II (la) antigens in immunologically-mediated renal injury. To study the role of PT as accessory cells, we generated several murine PT-like ...
2021年3月瑞士苏黎世大学实验免疫学研究所病毒免疫生物学教授Christian Münz于Nature communications发表文章Oxidation inhibits autophagy protein deconjugation from phagosomes to sustain MHC class II restricted antigen presentation其研究发现N...
To play their part in the generation of effective adaptive immune responses, different types of antigen-presenting cell (APC) take up and process antigen in different ways. The length of time that peptide–MHC class II complexes are present on APC surfac
ProT2® MHC Class II Tetramers allow you to detect single antigen-specific CD4+T cells accurately by flow cytometry. They can also be used to separate cells for culture, expansion and further study. ProT2® Tetramers enable you to study in depth CD4+ T cell immune responses in a wide...
Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthes...
This monoclonal antibody has been reported to inhibit mixed lymphocyte reactions and T cell activation induced by MHC Class II antigen presentation in vitro. Also, YKIX334.2 recognition of MHC Class II is not allele-specific. Applications Reported: This YKIX334.2 antibody has been reported for use...
During biosynthesis, MHC class II associates with invariant chain which exists in two forms, p31 and p41. Both forms of invariant chain prevent peptide binding to class II, facilitate transport, and enhance class II localization to Ag-processing compartments. In spite of these shared functions, ...
2. Roche PA, Furuta K. The ins and outs of MHC class II-mediated antigen processing and presentation.Nat Rev Immunol2015;15(4):203-16 doi 10.1038/nri3818. 3. Axelrod ML, Cook RS, Johnson DB, Balko JM. Biologic...