S. Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proc. Natl Acad. Sci. USA 102, 7910–7915 (2005). Article CAS PubMed PubMed Central Google Scholar Santambrogio, L. et al. Involvement of caspase-cleaved and intact ...
Major histocompatibility complex (MHC) class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB) are polymorphic proteins that are induced upon stress, damage or transformation of cells which act as a ‘kill me’ signal through the natural-killer group 2, member...
contains a sorting signal that directs trafficking of the major histocompatibility complex (MHC) class II: Ii oligomeric complex to endocytic compartments. Th... A Chervonsky,AJ Sant - 《European Journal of Immunology》 被引量: 3发表: 2010年 加载更多来源...
Sci. Signal., 9 (2016), Article ra69, 10.1126/scisignal.aaf0793 View in ScopusGoogle Scholar 46 E.A. Hughes, C. Hammond, P. Cresswell Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome Proc. Natl. Acad. Sci. ...
J and K: EnVision (J) and Tyramide signal amplification (TSA)46 (K) show the low expression of MHC class I in the vehicle-treated control follicle matrix and proximal ORS in cultured human hair follicles. L and M: 75 IU/m IFN-γ induces the ectopic MHC class I expression in human ...
Trafficking of superinfecting Mycobacterium organisms into established granulomas occurs in mammals and is independent of the Erp and ESX-1 mycobacterial v... Although tuberculous granulomas, which are composed of infected macrophages and other immune cells, have long been considered impermeable structures...
Establishment of an in vitro vesible generation assay to investigate intracellular trafficking of MHC class I molecules 来自 d-nb.info 喜欢 0 阅读量: 21 作者: B Borchert 摘要: Major histocompatibility complex (MHC) class I molecules bind viral peptides inside the Endoplasmic Reticulum (ER). The...
www.intechopen.com MHC Class I Quality Control 165 Fig. 1. The MHC-I protein structure allows short peptides to bind tightly in the peptide binding groove spanning the MHC-I 1/2-domains. A) Schematic structure of MHC-I, which consists of a HC with 3 -domains (light blue)...
Antigen presentation via major histocompatibility complex class I (MHC I) molecules is essential to mount an adaptive immune response against pathogens and cancerous cells. To this end, the transporter associated with antigen processing (TAP) delivers snippets of the cellular proteome, resulting from ...
Keywords: teleost; rayfinned fish; Major histocompatibility complex; MHC class I; MHC class II; phylogeny; evolution 1. Introduction Originally, the histocompatibility antigen (or the H2-locus) was defined as a gene with a major effect on tissue rejection in mice. Later, when it became obvious...