Major histocompatibility complex class I (MHC-I) molecules signal infection or transformation by engaging receptors on T lymphocytes. The spatial organization of MHC-I on the plasma membranes is important for this engagement. We and others have shown that MHC-I molecules, like other membrane protein...
MHC class I molecules contain within their cytoplasmic domains a tyrosine and two orthree serines that demonstrate a remarkable level of conservation between all mammalsand extending to species as evolutionarily distant as the shark and zebrafish. In order toexplore the role of these amino acids bot...
S. Involvement of clathrin and AP-2 in the trafficking of MHC class II molecules to antigen-processing compartments. Proc. Natl Acad. Sci. USA 102, 7910–7915 (2005). Article CAS PubMed PubMed Central Google Scholar Santambrogio, L. et al. Involvement of caspase-cleaved and intact ...
2f). Overall, our data demonstrate that TCR-MAP is readily adaptable to study mouse class I-restricted (H2-Kb) and class II-restricted (H2-IAb) TCR interactions and the magnitude of the signal is determined by the strength of the TCR–ligand interaction. Virome-wide screens and TCR ...
Down-regulation of MHC class I surface expression by MDV pUL49.5 The UL49.5 gene of MDV was modified by insertion of the coding sequences for a FLAG epitope after the predicted signal peptide and was cloned into the mammalian expression vector pcDNA3.1. The resulting recombinant plasmid was tran...
Sci. Signal., 9 (2016), Article ra69, 10.1126/scisignal.aaf0793 View in ScopusGoogle Scholar 46 E.A. Hughes, C. Hammond, P. Cresswell Misfolded major histocompatibility complex class I heavy chains are translocated into the cytoplasm and degraded by the proteasome Proc. Natl. Acad. Sci. ...
IntracellularassemblyandtraffickingofMCclassImolecules LINKailong,ZOULiyun,WANYing SeventeenTeamofTraineeBrigade,ThirdMilitaryMedicalUniversity,Chongqing400038,China [Abstract]MHCClassⅠmoleculesexpressonallnucleatedcellsandplayanimportantroleintriggering immuneresponse.MHCclassImoleculesbindpeptidefragmentsofintracellularprote...
Compartmentalization of MHC I assembly in the secretory pathway This study investigates the role of subcellular compartmentalization in assembly and export of Class I histocompatibility molecules (MHC I). Assembly of MH... PA Bresnahan,FM Brodsky - 《Human Immunology》 被引量: 0发表: 1996年 Redox...
Major histocompatibility complex (MHC) class I chain-related protein A (MICA) and MHC class I chain-related protein B (MICB) are polymorphic proteins that are induced upon stress, damage or transformation of cells which act as a ‘kill me’ signal through the natural-killer group 2, member...
Antigen presentation via major histocompatibility complex class I (MHC I) molecules is essential to mount an adaptive immune response against pathogens and cancerous cells. To this end, the transporter associated with antigen processing (TAP) delivers snippets of the cellular proteome, resulting from ...