Zebrafish Mhc class II a chain-encoding genes: polymorphism, expression, and function. Immunogenetics 38: 408–420, 1993Sultmann H, Mayer WE, Figueroa F, O'Huigin C, Klein J: Zebrafish Mhc class II alpha chain-encoding genes: polymorphism, expression, and function. Immunogenetics 1993;38:408...
Ⅱ类分子的表达, IFN-γ、IL-2、IL-4 和 IL-10 等细胞因子水平的变 化及心肌病理学的改变,为心肌炎的发病及特发性扩张性心肌病的预 后评估及治疗提供了实验依据。 方法:1. 猪心肌肌球蛋白致Balb/c 小鼠自身免疫性心肌疾病模型 的复制:近交系Balb/c 小鼠60 只,雌雄各半,8 周龄,体重16-20g, ...
21.2.2MHC Class II TheMHCclass II molecule (MHCII) is composed of twopolypeptide chains, α and β, each of which traverses the cell membrane and associates to form aheterodimercontaining two conserved immunoglobulin-like domains proximal to the cell membrane (α2β2) and two polymorphic domai...
Invariant chain structure and MHC class II function. Cell 84, 505–507 (1996). Article CAS PubMed Google Scholar Dugast, M., Toussaint, H., Dousset, C. & Benaroch, P. AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class ...
The retrograde transport of the medial Golgi enzyme N-acetylglucosamine transferase, however, required microtubular function. Microtubule disrupters could affect BFA treatment of viral infections by further disrupting viral protein processing. 展开 关键词: MHC class II-Ii brefeldin A nocodazole ...
Thus, B cells provide a critical cellular function in pathogenesis of central nervous system autoimmunity independent of their humoral involvement, findings which may be relevant to B cell-targeted therapies. 展开 关键词: EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS CENTRAL-NERVOUS-SYSTEM PROGRESSIVE MULTIPLE-...
MHCII基因反式作用子(class II transactivator, CIITA)在研究裸淋巴细胞综合征时被分离, 发现其通过影响MHCII的转录水平, 从而调节机体的免疫功能。现就CIITA调控MHCII基因转录的分子机制及可能的临床应用综述如下。1 CIITA的结构 人类CIITA基因位于16号染色体(16p13.13), 全长4543 bp。CIITA基因的转录在人类由4种...
Human MHC Class II Antigens: Genetics, Structure and Function Proceedings of the First International Workshop on Monoclonal Antibodies to Human MHC Class II Antigens Disease Markers (special issue) — Volume 2 Edited by H.M. Dick, C.M. Steel and B. Dupont John Wiley and Sons, Chichester ...
Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function. Mol. Immunol. 68, 98–101 (2015). Article CAS PubMed PubMed Central Google Scholar Abualrous, E. T. et al. F pocket flexibility influences the tapasin dependence of two differentially ...
2. 巨噬细胞将抗原呈递给T细胞，进而激活T细胞。3. 抗原呈递的过程不只需要MHC class I, 还需要只在...