The ability to activate CD4 T cells is restricted to antigen-presenting cells that express major histocompatibility complex (MHC) class II molecules. Parenchymal cells normally do not express MHC class II molecules; however, in clinical hepatitis, viral or autoimmune, hepatocytes often exhibit aberrant...
21.2.2MHC Class II TheMHCclass II molecule (MHCII) is composed of twopolypeptide chains, α and β, each of which traverses the cell membrane and associates to form aheterodimercontaining two conserved immunoglobulin-like domains proximal to the cell membrane (α2β2) and two polymorphic domai...
Invariant chain structure and MHC class II function. Cell 84, 505–507 (1996). Article CAS PubMed Google Scholar Dugast, M., Toussaint, H., Dousset, C. & Benaroch, P. AP2 clathrin adaptor complex, but not AP1, controls the access of the major histocompatibility complex (MHC) class ...
We have studied the DNA sequence elements of the murine MHC class II A beta gene involved in transcriptional regulation in macrophages. For this study, the A beta promoter was fused to the human growth hormone gene and transfected into bone marrow-derived macrophages. These macrophages were ...
Antigen-presenting cells (APCs) present peptide antigens in the context of the class-II major histocompatibility complex (MHC-II). During inflammatory conditions, epithelial cells express MHC-II and function as accessory APCs. Utilizing RNA-seq data from nearly 400 GC patients, we determined the ...
Eosinophils function in murine allergic airways inflammation as professional antigen-presenting cells (APCs). In murine professional APC cell types, optimal functioning of MHC Class II depends on its lateral association in plasma membranes and colocalization with the tetraspanin CD9 into detergent-resistan...
Ⅱ类分子的表达, IFN-γ、IL-2、IL-4 和 IL-10 等细胞因子水平的变 化及心肌病理学的改变,为心肌炎的发病及特发性扩张性心肌病的预 后评估及治疗提供了实验依据。 方法:1. 猪心肌肌球蛋白致Balb/c 小鼠自身免疫性心肌疾病模型 的复制:近交系Balb/c 小鼠60 只,雌雄各半,8 周龄,体重16-20g, ...
2. 巨噬细胞将抗原呈递给T细胞，进而激活T细胞。3. 抗原呈递的过程不只需要MHC class I, 还需要只在...
Humanized mice expressing Human Leukocyte Antigen (HLA) class I or II transgenes have been generated, but the role of class Ivsclass II on human T and B cell reconstitution and function has not been investigated in detail. Herein we show... S Majji,W Wijayalath,S Shashikumar,... - 《...
Plasticity of empty major histocompatibility complex class I molecules determines peptide-selector function. Mol. Immunol. 68, 98–101 (2015). Article CAS PubMed PubMed Central Google Scholar Abualrous, E. T. et al. F pocket flexibility influences the tapasin dependence of two differentially ...