WORKSHOP A: STRUCTURE AND FUNCTION OF MHC CLASS I AND CLASS IV MOLECULESFirst page of articledoi:10.1111/j.1744-313X.1987.tb00355.xG. B. FerraraJ. C. HowardJohn Wiley & Sons, Ltd (10.1111)International Journal of Immunogenetics
Through contact between inhibitory receptors and their MHC class I ligands, NK cells are rendered both self-tolerant, as well as functionally competent. The process of MHC class I-dependent acquisition of NK cell function is termed "licensing.".;Herein we devised an experimental system of ...
The ability to activate CD4 T cells is restricted to antigen-presenting cells that express major histocompatibility complex (MHC) class II molecules. Parenchymal cells normally do not express MHC class II molecules; however, in clinical hepatitis, viral or autoimmune, hepatocytes often exhibit aberrant...
They are built up of a large eight-stranded β-sheet with two mostly α-helical regions on top of the β-sheets. The MHC class I helices are formed by the α150-α155 and α158-α184 residues on one side of the peptide binding groove and by the α2138-α2148 and α2151-α2180...
Immunological recognition of transplanted tissues is not a requisite function selected evolutionarily, but rather reflects the robust capacity developed by the innate and adaptive immune systems to counter infection and neoplasia. The rejection of geneti
Rachel Carter1,3, Stephen Emmott2, Andrew Phillips2, Jörn M. Werner1,4 & Tim Elliott1,3 The selection of peptides for presentation at the surface of most nucleated cells by major histocompatibility complex class I molecules (MHC I) is crucial to the immune response in verte...
By using an MHC deficient cell line, we have shown that HCV core35-44 peptide is capable of enhancing cell surface expression of MHC class I (HLA-C and HLA-E). Although this peptide stabilises HLA-E, the HLA-E:HCV core35-44 complex alone is insufficient to inhibit at NKG2A positive ...
Retinal pigment epithelial (RPE) cells induced to express MHC class II (HLA-DR) by incubation with interferon gamma (IFN-±) were investigated for their ability to present a microbial superantigen to T lymphocytes. Superantigens bind to MHC class II antigens and appear to play a role in a...
Human MHC Class II Antigens: Genetics, Structure and Function Proceedings of the First International Workshop on Monoclonal Antibodies to Human MHC Class II Antigens Disease Markers (special issue) — Volume 2 Edited by H.M. Dick, C.M. Steel and B. Dupont John Wiley and Sons, Chichester ...
MCs constitutively express major histocom- patibility complex (MHC) class I and upregulate expression of MHC class II when stimulated with interferon- (IFN ), TNF, or lipopolysaccharide (Table 1).88–97 In addition to MHC, cos- timulatory molecules CD28, CD80, CD86, intercellular adhesion ...